工程纳米材料毒理学的研究现状与研究方法评价  

Review on research progress and methods of engineering nanomaterial toxicology

作　　者：沈建云 温海燕 姜楠 周萌 邢本 姜双林 SHEN Jianyun;WEN Haiyan;JIANG Nan;ZHOU Meng;XING Ben;JIANG Shuanglin(School of Biology and Food Engineering,Fuyang Normal University,Fuyang Anhui 236037,China;Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province,Fuyang Anhui 236037,China)

机构地区：[1]阜阳师范大学生物与食品工程学院,安徽阜阳236037 [2]胚胎发育与生殖调节安徽省重点实验室,安徽阜阳236037

出　　处：《阜阳师范学院学报（自然科学版）》2019年第4期38-43,共6页Journal of Fuyang Normal University(Natural Science)

基　　金：国家自然科学基金项目(91643113,21637004)资助

摘　　要：工程纳米材料(Engineered nanomaterials,ENM)因独特的理化性质,使其在纳米药学和纳米医学领域具有良好的应用前景。同时,其独特的理化性质特性也可引起一些健康风险问题。目前关于ENM细胞摄取、跨生物屏障的转运、体内分布以及可能的毒性机制仍然知之甚少。本文系统综述了ENM的理化性质、表征、暴露方式、毒理评价以及安全性等关键问题,为纳米材料的毒理学研究和安全评价提供参考。Engineered nanomaterials(ENM)was widely used in the research of pharmacology and nanomedicine due to its unique physical and chemical properties.At the same time,its unique physical and chemical properties can also cause some health risk problems.Little is known about ENM cell uptake,transport across biological barriers,distribution in vivo,and possible toxic mechanisms.In this paper,the physicochemical properties,characterization,exposure mode,toxicological evaluation and safety of ENM were systematically reviewed to provide reference for the toxicological research and safety evaluation of nanomaterials.

关 键 词：工程纳米材料 纳米毒理学 体内毒性 体外毒性 安全评价 

分 类 号：X965[环境科学与工程—安全科学]