FT3水平对行经皮冠状动脉介入治疗且甲状腺功能正常的急性冠状动脉综合征患者预后的影响  

Effect of FT3 Levels on the Prognosis of Patients with Normal Thyroid Function and Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

作　　者：孙娜[1] 孙兆青[1] 于彤彤[1] 焦云娣[1] 何东旭[1] 田春阳[1] 宋佳[1] 温宗玉 武佳科 孙志军[1] 张贺[1] SUN Na;SUN Zhaoqing;YU Tongtong;JIAO Yundi;HE Dongxu;TIAN Chunyang;SONG Jia;WEN Zongyu;WU Jiake;SUN Zhijun;ZHANG He(Department of Cardiology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院心血管内科

出　　处：《中国医科大学学报》2019年第11期1016-1019,共4页Journal of China Medical University

摘　　要：目的探讨游离三碘甲状腺原氨酸(FT3)水平对行经皮冠状动脉介入治疗(PCI)且甲状腺功能正常的急性冠状动脉综合征(ACS)患者预后的影响。方法选择2015年1月1日至2016年7月31日于中国医科大学附属盛京医院心内科住院确诊为ACS且行PCI的患者1 391例,测定其FT3水平,基于受试者工作特征(ROC)曲线确定FT3的最佳界值为3.68 mmol/L。将患者分为FT3较低组和FT3较高组,统计2组的临床资料,随访术后1年全因死亡事件,使用单因素及多因素Cox回归模型分析FT3水平与患者预后的相关性。结果与FT3较高组比较,FT3较低组患者年龄较高,男性比例更低,既往存在高血压、糖尿病及心力衰竭病史的患者比例更高。FT3较低组患者术后1年全因死亡率高于FT3较高组(P <0.05)。Cox回归分析表明,FT3水平与术后1年全因死亡(HR=1.022,P <0.05)独立相关。结论在甲状腺功能正常的行PCI的ACS患者中,FT3水平与PCI术后1年全因死亡相关。Objective To investigate the effect of free triiodothyronine(FT3) on the prognosis of patients with acute coronary syndrome and normal thyroid function undergoing percutaneous coronary intervention. Methods From January 1,2015 to July 31,2016,1 391 patients with acute coronary syndrome who underwent percutaneous coronary intervention at the Department of Cardiology,Shengjing Hospital,China Medical University,were included in this study. Their FT3 levels were measured. The optimal critical point of FT3 was 3.68 mmol/L based on receiver operating characteristic curves,and the patients were divided into two groups:lower and higher FT3. The clinical data were compared,and 1-year all-cause mortality was recorded. Results Compared with the higher FT3 group,the lower FT3 group was older and had a lower proportion of males and higher proportion of patients with a history of hypertension,diabetes,or heart failure(P < 0.05). Cox regression analysis showed that the level of FT3 was independently associated with 1-year all-cause mortality after percutaneous coronary intervention(HR = 1.022,P < 0.05). Conclusion In patients with acute coronary syndrome and normal thyroid function,FT3 levels are associated with 1-year all-cause mortality after percutaneous coronary intervention.

关 键 词：游离三碘甲状腺原氨酸 急性冠状动脉综合征 经皮冠状动脉介入治疗 预后 

分 类 号：R541.4[医药卫生—心血管疾病]