HIV感染者外周血CD4^+T淋巴细胞数与血常规、肾功能及血淀粉酶的关系  

Correlation between Different Immune Levels and Blood Routine, Renal Function and Serum Amylase of HIV Patients

作　　者：杨水秀 国果 YANG Shuixiu;GUO Guo(School of Basic Medicine,Guizhou Medical University,Guiyang 550025,Guizhou,China;Dialysis Room,Guiyang Public Health Clinical Center,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学基础医学院,贵州贵阳550025 [2]贵阳市公共卫生救治中心血透室,贵州贵阳550004

出　　处：《贵州医科大学学报》2019年第11期1305-1309,共5页Journal of Guizhou Medical University

基　　金：国家自然科学基金项目(81760647)

摘　　要：目的:探讨人类免疫缺陷病毒(HIV)感染者外周血CD4^+T淋巴细胞数与血常规、肾功能及血淀粉酶的关系。方法:326例HIV感染者为研究组,根据CD4^+T淋巴细胞计数分为3组(A组CD4^+T淋巴细胞数<200个/μL、B组CD4^+T淋巴细胞数200~500个/μL、C组CD4^+T淋巴细胞数>500个/μL),另选取同期健康体检者100例为对照组;比较对照组和研究组ART前,研究组ART前后的CD4^+T淋巴细胞计数、白细胞计数(WBC)、淋巴细胞计数(LY)、淋巴细胞百分比(LY%)、中性粒细胞计数(Neu)、中性粒细胞百分比(Neu%)、尿素氮(BUN)、肌酐(CRE)、胱抑素-C(Cys-C)、β2-微球蛋白(β2-MG)、血淀粉酶(AMY),Pearson相关分析研究组患者治疗后CD4^+T淋巴细胞计数与这些指标的相关性。结果:与对照组比较,治疗前3组HIV感染者的WBC、LY、LY%均降低,β2-MG均升高,差异有统计学意义(P<0.05);治疗前3组HIV感染者间比较,WBC、LY、LY%随CD4^+T淋巴细胞计数减少而下降,Neu%、β2-MG随CD4^+T淋巴细胞计数减少而升高,差异有统计学意义(P<0.05);ART 6月时,3组HIV感染者LY、LY%较治疗前均升高,Neu%、Cys-C、β2-MG较治疗前均降低,A组β2-MG水平高于B组和C组,差异有统计学意义(P<0.05);Pearson相关分析结果显示,A组与B组的CD4^+T淋巴细胞与WBC、LY、LY%呈正相关(P<0.05),与Neu%、Cys-C、β2-MG呈负相关(P<0.05)。结论:HIV感染者外周血CD4^+T淋巴细胞计数与血常规、肾功能指标具有一定相关性,检测血常规、肾功能指标对制定治疗方案、监测疗效、及时调整诊疗方案具有一定的指导意义。Objective:To investigate the changes of white blood cells(WBC),lymphocyte count(LY),lymphocyte percentage(LY%),neutrophil counts(Neu),percentage of neutrophils(Neu%),urea nitrogen(BUN),creatinine(CRE),Cystatin-C(Cys-C),β2-micro globulin(β2-MG)and serum amylase(AMY),and its correlation with different immune levels of patients with HIV.Methods:The test data of 326 cases of HIV infected people before and after 6 months'ART was collected including CD4^+T-lymphocyte counts,WBC,LY,LY%,Neu,Neu%,BUN,CRE,Cys-C,β2-MG and serum AMY.Based on detection of CD4^+T-lymphocyte counts before treatment,they were divided into three groups:Group A(CD4^+T-lymphocyte counts<200/μL),Group B(CD4^+T-lymphocyte counts 200~500/μL)and Group C CD4^+T-lymphocyte counts>500/μL).Results:The levels of WBC,LY and LY%in all groups decreased,whileβ2-MG increased compared with the control group before ART(P<0.05).With the decrease of immune level(CD4^+T-lymphocyte counts),the levels of WBC,LY and LY%of HIV infection in all groups showed a downward trend(P<0.05),β2-MG gradually increased(P<0.05).After 6-months'ART,the levels ofβ2-MG in Group A were higher than those of Group B and Group C(P<0.05).LY and LY%after ART were higher than before ART,while the levels of Neu%,Cys-C andβ2-MG declined after ART(P<0.05).Pearson analysis showed that the CD4^+T-lymphocyte counts in HIV patients were positively correlated with LY and LY%,and negatively correlated with GR%,Cys-C andβ2-MG.The levels of CD4^+T-lymphocyte counts were not significant correlated with WBC,Neu,BUN,CRE and AMY.Conclusion:Monitoring the above indicators can provide certain clinical guiding significance for the treatment options,adjust and monitoring efficacy.

关 键 词：HIV感染 CD4^+T淋巴细胞计数 血常规 肾功能 Β2-微球蛋白 胱抑素-C 淀粉酶 

分 类 号：R512.91[医药卫生—内科学]