羊毛角蛋白/聚乙烯醇共混膜的制备及药物缓释分析  

Preparation of wool keratin/polyvinyl alcohol blend membrane and analysis of the drug sustained-release

作　　者：夏平 王威[1] 徐磊[1] XIA Ping;WANG Wei;XU Lei(School of Textile,Tiangong University,Tianjin 300387,China)

机构地区：[1]天津工业大学纺织学院

出　　处：《上海纺织科技》2019年第11期42-45,51,共5页Shanghai Textile Science & Technology

摘　　要：采用浇铸法制备出具有不同质量比的羊毛角蛋白/聚乙烯醇(PVA)共混膜,通过加载药物甲硝唑,研究了其药物缓释性能。结果表明,当羊毛角蛋白与聚乙烯醇的质量比为1∶9时,共混膜光滑平整、致密均匀,抗拉强度最好,溶胀率最大。FTIR测定分析表明,角蛋白和聚乙烯醇属于物理混合。药物缓释测试结果显示,羊毛角蛋白/聚乙烯醇(PVA)载药共混膜具有药物缓释功能,且随着羊毛角蛋白含量的增加,载药共混膜的药物缓释能力增强。The wool keratin/polyvinyl alcohol(PVA)blend membrane with different mass ratios is prepared by casting method,and the drug is loaded with metronidazole.The drug sustained-release function is studied.The results show that when the mass ratio of wool keratin to polyvinyl alcohol is 1∶9,the blend membrane is smooth and uniform with the best tensile strength and the highest swelling ratio.FTIR analysis shows that keratin and polyvinyl alcohol belong to Physical mixing.The drug sustained-release test results show that wool keratin/polyvinyl alcohol(PVA)drug-loaded blend membrane has drug sustained-release function,and with the increase of wool keratin content,the drug-loaded blend membrane could improve the drug sustained-release ability.

关 键 词：羊毛角蛋白 聚乙烯醇 共混膜 力学性能 溶胀率 药物缓释 

分 类 号：TS177[轻工技术与工程—纺织材料与纺织品设计]