1例临床药师优化坏死性筋膜炎患者抗感染治疗方案的药学实践  

Pharmaceutical practice of clinical pharmacist in optimizing one case of necrotizing fasciitis treated with anti-infective therapy

作　　者：马红艳 陈燕[2] 王仙[1] 蔡光欣[1] MA Hong-yan;CHEN Ya;WANG Xian;CAI Guang-xin(Department of Pharmacy,Jingzhou First People's Hospital,Hubei Jingzhou 434000,China;Department of Pharmacy,Shanghai Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]荆州市第一人民医院药学部,湖北荆州434000 [2]上海市第六人民医院药学部,上海200233

出　　处：《临床药物治疗杂志》2019年第10期82-84,共3页Clinical Medication Journal

摘　　要：临床药师参与1例罕见坏死性筋膜炎危重症患者的救治过程,运用药学知识结合患者病情,选择合适抗感染药物治疗方案。患者初始抗感染方案为利奈唑胺联合亚胺培南,后加用青霉素,在获取病原学结果后,针对泛耐药鲍曼不动杆菌感染,结合细菌敏感性试验,多次调整抗感染方案,确定以多黏菌素B联合舒巴坦复合制剂为基础的联合用药方案,患者临床症状及感染指标逐渐好转。临床药师参与临床药物治疗,对危重症患者展开药学服务,对少见疾病的治疗方案制定个体化给药方案,最大程度减少药物的不良反应,确保临床治疗安全、有效。Clinical pharmacist participated in the treatment of a patient with rare necrotizing fasciitis critical,including applying pharmaceutical knowledge according to the patient’s condition and selecting the appropriate anti-infective drug treatment.Initial anti-infective medicines were linezolid combined with imipenem,followed by penicillin.After obtaining the etiological results,combined with bacterial susceptibility tests,the pharmacists adjusted the anti-infective regimen several times and chose the combination of polymyxin B and sulbactam based on the results of pathogenic analysis.The patient’s clinical symptoms and infection indicators gradually improved Clinical pharmacists took part in clinical drug treatment,provided pharmaceutical care to critically ill patients,and formulated individualized dosage regimens for rare diseases,so as to minimize adverse drug reactions and ensure the safety and effectiveness of clinical treatment.

关 键 词：坏死性筋膜炎 危重症患者 抗感染方案 

分 类 号：R686[医药卫生—骨科学] R969.3[医药卫生—外科学]