阻塞性睡眠呼吸暂停低通气综合征患者血清ADMA、ET-1、VWF水平及临床意义  

ADMA, ET-1 and VWF serum levels in patients with obstructive sleep apnea hypopnea syndrome in Uygur and Han nationality and their clinical significance

作　　者：郑爱芳[1] 钟雪梅[1] 李菲菲 马涛 古兰白尔·阿不都热西提 李黎[1] ZHENG Ai-fang;ZHONG Xue-mei;LI Fei-fei;MA Tao;ABUDUREXITI Gulanbaier;LI Li(Department of Respiratory and Critical Care Medical,Kashgar Region of First People s Hospital,Kashgar,Xinjiang 844000,China)

机构地区：[1]喀什地区第一人民医院呼吸与危重症医学一科

出　　处：《临床肺科杂志》2019年第12期2166-2170,共5页Journal of Clinical Pulmonary Medicine

基　　金：喀什地区科技计划项目(No KS2017023)

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清ADMA、ET-1、VWF水平及临床意义。方法选择2017年3月到2018年3月在喀什地区第一人民医院住院或者门诊确诊的维吾尔族OSAHS患者63例和汉族OSAHS患者31例作为病例组,选择同期在医院体检的维吾尔族健康人群75例和汉族健康人群40例作为正常对照组,测定维吾尔族、汉族病例组和对照组人群的血清ADMA、ET-1、VWF水平,并收集一般信息和临床资料。结果维吾尔族、汉族OSAHS患者的BMI、收缩压、舒张压、颈围、腹围、AHI较健康对照组高,(P<0.05)。以上两组患者血清ADMA、ET-1、VWF水平明显高于健康对照组,(P<0.05)。维吾尔族OSAHS患者血清ADMA、ET-1、VWF水平以及BMI、颈围、腹围、AHI数值高于汉族OSAHS患者,(P<0.05)。OSAHS患者血清ADMA、ET-1、VWF与病情严重程度相关,随着OSAHS患者病情严重程度的增加,OSAHS患者血清ADMA、ET-1、VWF水平也增加,(P<0.05)。结论OSAHS患者血清ADMA、vWF、ET-1水平的检测有助于综合评估OSAHS患者的病情严重程度,早期发现内皮受损,为临床的早期干预提供依据,提高临床治疗效果,改善患者预后。Objective To investigate the serum levels of ADMA,ET-1 and VWF in Uygur and Han patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and their clinical significance.Methods 63 patients with Uygur OSAHS diagnosed in the First People s Hospital of Kashgar from March 2017 to March 2018,and 31 patients with Han OSAHS were selected as the case group.75 Uygur healthy people and 40 Han healthy people were selected as the normal control group.Serum levels of ADMA,ET-1,and VWF were measured in the case group and the control group,and their general information and clinical data were collected.Results BMI,systolic blood pressure,diastolic blood pressure,neck circumference,abdominal circumference and AHI in Uygur and Han OSAHS patients were higher than those in the healthy control group(P<0.05).The serum levels of ADMA,ET-1 and VWF in the above two groups were significantly higher than those in the healthy control group(P<0.05).The levels of ADMA,ET-1,VWF,BMI,neck circumference,abdominal circumference and AHI in Uygur OSAHS patients were higher than those in Han OSAHS patients(P<0.05).Serum ADMA,ET-1,and VWF in OSAHS patients were associated with the severity of disease.As the severity of OSAHS patients increased,serum ADMA,ET-1,and VWF levels in OSAHS patients also increased(P<0.05).Conclusion The detection of serum ADMA,vWF and ET-1 levels in patients with OSAHS is helpful to comprehensively evaluate the severity of OSAHS patients and early detection of endothelial damage,providing a basis for clinical early intervention,improving clinical efficacy and prognosis.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 非对称型二甲基精氨酸 血清内皮素-1 血管性血友病因子 

分 类 号：R54[医药卫生—心血管疾病]