荷瘤小鼠体内光敏胶束制剂的分布研究  

The distribution ofphotosensitive micelle nanocomposites in tumor-burdened mice

作　　者：宋素异[1] 杜斌[2] 沈国鹏[3] SONG Su-yi;DU Bin;SHEN Guo-peng(The Pharmaceutical Department of Zhengzhou First People's Hospital,Henan Zhengzhou 450004,China;Pharmacy College of Zhengzhou University,Henan Zhengzhou 450004,China;School of Chemical Engineering and Energy of Zhengzhou University.Henan Zhengzhou 450004,China)

机构地区：[1]郑州市第一人民医院药学部,河南郑州450004 [2]郑州大学药学院,河南郑州450004 [3]郑州大学化工与能源学院,河南郑州450004

出　　处：《中国医院药学杂志》2019年第21期2141-2146,共6页Chinese Journal of Hospital Pharmacy

基　　金：河南省科技发展项目(编号:152102310071)

摘　　要：目的:考察C60/Fe3O4-UCNPs@DTX@SNSC在荷瘤小鼠体内的分布特征。方法:采用高效液相色谱法,记录色谱图,计算C60/Fe3O4-UCNPs@DTX@SNSC在体内的血药浓度和组织浓度。结果:C60/Fe3O4-UCNPs@DTX@SNSC在肿瘤组织中的药物浓度相对较大。结论:制备的C60/Fe3O4-UCNPs@DTX@SNSC能够能够显著延长药物在体内的半衰期,增强其抗肿瘤效果。OBJECTIVE To investigate the distribution of C60/Fe3O4-UCNPs@DTX@SNSC nanocomposites in tumor-burdened mice. METHODS The HPLC method was used to record the chromatograms and calculate the plasma and tissue concentrations of C60/Fe3O4-UCNPs@DTX@SNSC. RESULTS The concentration of C60/Fe3O4-UCNPs@DTX@SNSC in tumor tissue was relatively high. CONCLUSION The prepared C60/Fe3O4-UCNPs@DTX@SNSC can significantly prolong the half-life of the drug in vivo and enhance its antitumor effect.

关 键 词：光敏胶束 荷瘤小鼠 组织分布 

分 类 号：R969[医药卫生—药理学]