广东汉族人群GLUT1基因rs3754219位点单核苷酸多态性与2型糖尿病遗传易感性研究  

Relationship between GLUT1 rs3754219 single nucleotide polymorphism and genetic susceptibility to type 2 diabetes mellitus in Han population in Guangdong Province

作　　者：闫妍 杨辉煌 胡维 徐霖 王姝 王星杰 谢宇荀 孔丹莉 潘海燕 丁元林 于海兵 YAN Yan;YANG Huihuang;HU Wei;XU Lin;WANG Shu;WANG Xingjie;XIE Yuxun;KONG Danli;PAN Haiyan;DING Yuanlin;YU Haibing(Department of Epidemiology and Medical Statistics,Guangdong Medical University,Dongguan,Guangdong 523808,P.R.China)

机构地区：[1]广东医科大学流行病与卫生统计学教研室

出　　处：《华西医学》2019年第11期1274-1278,共5页West China Medical Journal

基　　金：国家自然科学基金(81273166);广东省医学科研基金项目(B2018074);广东省自然科学基金(2016A030313674);广东省科技发展专项资金(基础与应用基础研究方向)博士科研启动(2018A030310115);广东省大学生创新训练项目(201810571102);广东高校省级重点平台和重大科研特色创新类项目(2017KTSCX084);东莞市社会科技发展(一般)项目(20185071521339);深圳市技术创新计划技术攻关项目(JSGG2010331103247408);东莞市社会科技发展项目(2016108101028)

摘　　要：目的探讨广东地区汉族人群葡萄糖转运蛋白(glucose transporters 1,GLUT1)基因rs3754219位点单核苷酸多态性(single nucleotide polymorphism,SNP)与2型糖尿病(type 2 diabetes mellitus,T2DM)遗传易感性的关系。方法 2011年11月-2014年10月,纳入10所医院确诊为T2DM的1 092例患者为病例组,同期1 092例健康人群为对照组。剔除SNP分型缺失率>20%(37例)和SNP位点均分型失败个体(26例),最终纳入病例组1 067例,对照组1 054例。使用SNPscan TM技术检测两组人群GLUT1基因rs3754219位点的基因型,分析其基因型、等位基因频率和不同遗传模型在两组中的分布差异。结果经年龄及体质量指数校正后,rs3754219位点的等位基因频率、多态性基因型频率比较,差异均无统计学意义(P>0.05)。在不同遗传模型下两组间比较,差异亦均无统计学意义(P>0.05)。结论广东地区汉族人群T2DM患者遗传易感性可能与GLUT1 rs3754219位点SNP无关。Objective To investigate the association between single nucleotide polymorphism(SNP) rs3754219 in the glucose transporters 1(GLUT1) gene and genetic susceptibility to type 2 diabetes mellitus(T2 DM) in Han population in Guangdong Province. Methods A total of 1 092 T2 DM patients(case group) and 1 092 healthy controls(control group) diagnosed or examined between November 2011 and October 2014 form 10 hospitals were enrolled in this study. SNPscan TM SNP classification technology was used to detect the polymorphism of rs3754219 of GLUT1 genetype.Finally, 1 067 T2 DM patients and 1 054 healthy controls were included, removing 37 individuals with SNP typing deletion rates >20% and 26 individucals with failed SNP site genotyping. The differences in allele frequency distribution, genotype,and genetic models between the two groups were analyzed. Results After correction for age and body mass index, there was no statistically significant difference in allele frequency or polymorphism genotype frequency of rs3754219(P>0.05).There was no statistically significant difference between the two groups under different genetic models(P>0.05).Conclusion Genetic susceptibility to T2 DM in Han population in Guangdong Province may be unrelated to the GLUT1 rs3754219 SNP.

关 键 词：2型糖尿病 单核苷酸多态性 GLUT1基因 

分 类 号：R58[医药卫生—内分泌]