探讨不同剂量秋水仙碱治疗痛风急性发作的临床疗效  

Discussion on clinical efficacy of colchicine at different doses on acute attack of gout

作　　者：刘丹阳[1] 田丰秋[1] 任丽媛[1] 谢万均[1] 于鑫淼[1] 王丹[1] LIU Dan-yang;TIAN Feng-qiu;REN Li-yuan(Department of Endocrinology,Dalian Friendship Hospital,Dalian 116001,China)

机构地区：[1]大连市友谊医院内分泌一科

出　　处：《中国现代药物应用》2019年第22期127-129,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨不同剂量秋水仙碱治疗痛风急性发作的临床疗效。方法60例痛风急性发作患者,按照秋水仙碱使用剂量不同分为对照组和试验组,各30例。试验组患者给予秋水仙碱片1 mg/次,3次/d;对照组患者给予秋水仙碱片1 mg/次,1次/2 h。比较两组患者疼痛缓解情况及缓解时间。结果试验组患者疼痛缓解率为86.7%,明显高于对照组的63.3%,差异有统计学意义(P<0.05)。试验组患者疼痛缓解时间为(26.2±9.2)h,对照组患者疼痛缓解时间为(41.6±12.5)h;试验组患者疼痛缓解时间明显短于对照组,差异有统计学意义(P<0.05)。结论口服秋水仙碱1 mg/次及3次/d治疗痛风急性发作患者疗效显著,可以缓解患者疼痛,加速炎症消退,值得临床推广与应用。Objective To discuss the clinical efficacy of colchicine at different doses on acute attack of gout.Methods A total of 60 patients with acute attack of gout were divided into control group and experimental group by different doses of colchicine,with 30 cases in each group.The experimental group was treated by colchicine tablets 1 mg/time,3 times/d,and the control group was treated by colchicine tablets 1 mg/time,1 time/2 h.The pain remission status and remission time in the two groups was compared.Results The pain remission rate in the experimental group was 86.7%,which was obviously higher than 63.3%in the control group,and the difference was statistically significant(P<0.05).The pain remission time was(26.2±9.2)h,which was(41.6±12.5)h in the control group.The pain remission time in the experimental group was obviously shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Oral colchicine 1 mg/time and 3 times/d has a significant effect on patients with acute gout attack.It can alleviate the pain of patients,accelerate the regression of inflammation,and is worthy of clinical promotion and application.

关 键 词：痛风 秋水仙碱 不同剂量 

分 类 号：R47[医药卫生—护理学]