脂质体药用辅料DMPG的合成研究  

Synthesis of pharmaceutical excipients of liposomes DMPG

作　　者：刘霞[1] 苏长会 潘涛[1] 沈宏[1] 黄兆琴[1] LIU Xia;SU Chang-hui;PAN Tao;SHEN Hong;HANG Zao-qin(College of Environment Science and ecology,Jiangsu Open University,Nanjing 210036,China;School of Chemistry and Life Science,Nanjing University Jinling College,Nanjing 210089,China)

机构地区：[1]江苏开放大学环境生态学院,江苏南京210036 [2]南京大学金陵学院化学与生命科学学院,江苏南京210089

出　　处：《化学研究与应用》2019年第11期1991-1994,共4页Chemical Research and Application

基　　金：江苏省高校自然科学基金项目(16KJB150007)资助;江苏开放大学十三五规划课题项目(17SSW-Z-Y-023)资助;江苏开放大学“纳米功能材料研发及环保应用研究团队”项目(102916101)资助

摘　　要：以三氯氧磷、1,2-二肉豆蔻酰甘油及甘油缩丙酮为原料,通过磷酰化、水解等反应合成1,2-二肉豆蔻酰磷脂酰甘油(DMPG),反应收率为75.8%,其结构经过IR,MS,1H NMR及13C NMR等确证。该合成方法具有操作简单、条件温和、收率高等特点。DMPG was synthesized by phosphorylation reaction and hydrolysis reaction with phosphorus oxychloride,1,2-ditetradecanoyl glycerol and acetone glycerol as raw materials,and the yield was 75.8%.DMPG was characterized by IR analysis,mass spectrometry,1H NMR and 13C NMR spectroscopy.This process could overcome many scale-up challenges that existed in the methods reported in the literature and provided an easy,mild and high yield route for large scale synthesis of DMPG.

关 键 词：三氯氧磷 脂质体 磷脂 合成 

分 类 号：O626[理学—有机化学]