早期微量低分子肝素区域动脉灌注治疗高脂血症性急性胰腺炎的效果及对氧化应激、炎症反应的影响  

Effect of Early Regional Arterial Infusion of Low Molecular Weight Heparin on Hyperlipidemic Acute Pancreatitis and Its Influence on Oxidative Stress and Inflammatory Response

作　　者：刘永庆 LIU Yongqing(Lushan People’s Hospital,Lushan 332800,China)

机构地区：[1]江西省庐山市人民医院

出　　处：《中国医学创新》2019年第30期13-17,共5页Medical Innovation of China

摘　　要：目的:研究早期微量低分子肝素区域动脉灌注治疗高脂血症性急性胰腺炎(HPL)的效果及对氧化应激、炎症反应的影响。方法:选取2016年9月-2019年3月在本院接受诊治的60例HPL患者,按照病历编号单双数将其分为研究组和对照组,各30例。研究组行早期微量低分子肝素区域动脉灌注治疗,对照组行静脉注射低分子肝素治疗,比较两组的治疗效果。结果:两组治疗总有效率比较,差异无统计学意义(P>0.05)。研究组APACHE-Ⅱ评分均低于对照组与治疗前(P<0.05)。两组MDA水平均低于治疗前,SOD水平和T-AOC水平均高于治疗前,且研究组均较对照组更优(P<0.05)。研究组炎性因子(CRP,TNF-α,IL-6、IL-8)水平均低于对照组与治疗前(P<0.05)。研究组并发症发生率为6.67%,对照组为26.67%,两组比较差异有统计学意义(P<0.05)。结论:早期微量低分子肝素区域动脉灌注治疗HPL可显著改善患者的病情,抑制机体氧化应激、炎症反应发生,降低并发症发生率,值得临床推广。Objective:To study the effect of early regional arterial infusion of Low Molecular Weight Heparin on hyperlipidemic acute pancreatitis(HPL),and its influence on oxidative stress and inflammatory response.Method:A total of 60 patients with HPL admitted to the hospital from September 2016 to March 2019 were selected,according to the single and double number of medical records,60 patients were divided into the study group and the control group,30 cases in each group.The study group treated with early regional arterial infusion of Low Molecular Weight Heparin,while the control group treated with intravenous infusion of Low Molecular Weight Heparin,the therapeutic effects of two groups were compared.Result:There was no significant difference in the total effective rate of treatment between two groups(P>0.05).The APACHE-Ⅱscores in the study group were lower than those in the control group and before treatment(P<0.05).The MDA level in study group were significantly lower than that of before treatment and control group,SOD level and T-AOC level were significantly higher than those of before treatment and control group(P<0.05).The levels of Inflammatory factor(CRP,TNF-α,IL-6 and IL-8)in the study group were significantly lower than those of before treatment and the control group(P<0.05).The incidence of complications in the study group was 6.67%,the control group was 26.67%,there was a significant difference between two groups(P<0.05).Conclusion:Early regional arterial infusion of Low Molecular Weight Heparin can significantly improve the condition of patients with HPL,inhibit the occurrence of oxidative stress and inflammation,and reduce the incidence of complications,which is worthy of clinical promotion.

关 键 词：低分子肝素 区域动脉灌注 高脂血症性急性胰腺炎 炎症反应 氧化应激 

分 类 号：R47[医药卫生—护理学]