复方麝香注射液联合依达拉奉对颅脑外伤患者凝血和神经功能的影响分析  

Efficacy of the compound Shexiang injection plus edaravone on coagulation and nerve function in patients with craniocerebral trauma

作　　者：纪国敏 王闰 宋晓红 姜艳 Ji Guomin

机构地区：[1]牡丹江医学院附属红旗医院

出　　处：《中医临床研究》2019年第29期69-72,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探究将复方麝香注射液联合依达拉奉应用于颅脑外伤患者治疗中的效果,评价其对患者凝血功能、神经功能造成的影响,分析其治疗安全性。方法:在我院数据库中2017年9月-2018年10月收入的所有颅脑外伤患者的一般资料,根据本次实验要求选择其中42例患者作为实验对象,将所有患者随机均分两组,分别命名为对照组与实验组,每组21例患者。对照组患者应用依达拉奉注射液治疗,实验组患者则在此治疗基础上加用复方麝香注射液治疗,对比两组患者治疗前后的神经功能缺损评分、血清神经元特异性烯醇化酶水平、C反应蛋白水平、凝血酶原时间。评价两组患者治疗后的不良反应发生率,分析其用药效果。结果:两组患者在治疗前两组美国卫生研究院提出的卒中量表(The National Institutes of Health Stroke Scale,NIHSS)评分比较,其差异不明显,但在治疗后实验组患者的NIHSS评分明显优于对照组,差异显著。同时两组患者的血清神经元特异性烯醇化酶水平、C反应蛋白水平、凝血酶原时间差异有统计学意义(P<0.05);实验组患者治疗后的不良反应发生率与对照组相比未见明显差异,不具有统计学意义(χ^2=0,P=1)。结论:在对颅脑外伤患者进行治疗时,应用复方麝香注射液配合依达拉奉进行联合用药,能够有助于改善患者的凝血功能和神经功能,有助于减轻患者颅脑损伤状况,对于患者预后改善来说有积极意义,同时也不会引起患者发生其他用药不良反应,是一种安全且有效的治疗方案,值得推广使用。Objective:To investigate efficacy of the compound Shexiang injection(复方麝香注射液)plus edaravone on coagulation and nerve function in patients with craniocerebral trauma.Methods:42 cases were divided into two groups,21 cases in each.The control group was given edaravone;and the experimental group was given the compound Shexiang injection more.Results:After treatment,the NIHSS score in the experimental group was significantly better than that of the control group,and the difference was significant.Serum neuron-specific enolase levels,C-reactive protein levels,and prothrombin time were significantly different between the two groups(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(χ^2=0,P=1).Conclusion:The compound Shexiang injection plus edaravone on coagulation and nerve function in patients with craniocerebral trauma shows good effects,can improve coagulation function and nerve function,reduce craniocerebral injury and adverse reactions,and is worth promoting.

关 键 词：复方麝香注射液 依达拉奉 颅脑外伤 凝血 神经功能 

分 类 号：R651.15[医药卫生—外科学]