自拟清疸汤联合熊去氧胆酸治疗淤胆型肝炎(肝胆湿热证)临床研究  

Clinical Study on Self-Made Qingdan Decoction Combined with Ursodeoxycholic Acid in the Treatment of Cholestatic Hepatitis(Liver-Gallbladder Dampness-Heat Syndrome)

作　　者：吴小林 王文华 夏平 李航 WU Xiaolin;WANG Wenhua;XIA Ping;LI Hang(Department of Pharmacy,Dazu District People′s Hospital,Chongqing,China 402360;Department of Traditional Chinese and Western Medicine,Dazu District People′s Hospital,Chongqing,China 402360)

机构地区：[1]重庆市大足区人民医院药学部,重庆402360 [2]重庆市大足区人民医院中西医结合科,重庆402360

出　　处：《中国药业》2019年第23期46-48,共3页China Pharmaceuticals

基　　金：重庆市大足区科技计划项目[DZKJ,2014ACC1072]

摘　　要：目的探讨自拟清疸汤联合熊去氧胆酸(UDCA)治疗淤胆型肝炎(肝胆湿热证)的疗效及安全性。方法选取医院消化内科2016年1月至2018年2月收治的淤胆型肝炎(肝胆湿热证)患者42例,随机分为对照组和治疗组,各21例。两组患者均给予熊去氧胆酸胶囊,治疗组加用自拟清疸汤。两组疗程均为2个月。结果治疗组中医证候总积分远低于对照组(P<0.05);治疗后,两组血清总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、γ-谷氨酰转酞酶(GGT)水平均低于治疗前(P<0.05),且治疗组显著低于对照组(P<0.05);治疗组临床总有效率为95.24%,显著高于对照组的66.67%(P<0.05);治疗组不良反应发生率显著低于对照组(0比33.33%,P<0.05)。结论自拟清疸汤联合熊去氧胆酸治疗淤胆型肝炎(肝胆湿热证)疗效确切,安全性高。Objective To investigate the efficacy and safety of self-made Qingdan Decoction combined with ursodeoxycholic acid(UDCA) in the treatment of cholestatic hepatitis(liver-gallbladder dampness-heat syndrome).Methods Totally 42 patients with cholestatic hepatitis(liver-gallbladder dampness-heat syndrome) admitted to the Department of Gastroenterology in our hospital from January 2016 to February 2018 were selected and divided into the control group and the treatment group,21 cases in each group.The patients in the two groups were given Ursodeoxycholic Acid Capsules,on this basis,the patients in the treatment group were treated with self-made Qingdan Decoction.The course of treatment in both groups was two months.Results The total score of traditional Chinese medicine(TCM) syndrome in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the levels of serum total bilirubin(TBiL),alanine aminotransferase(ALT),alkaline phosphatase(ALP) and γ-glutamyltransferase(GGT) in the two groups were lower than those before treatment(P<0.05),and those in the treatment group were significantly lower than those in the control group(P<0.05).The total clinical effective rate of the treatment group was 95.24%,which was significantly higher than66.67% of the control group(P<0.05).The incidence of the adverse reaction in the treatment group was lower than that of the control group(0 vs.33.33%,P<0.05).Conclusion Self-made Qingdan Decoction combined with UDCA is effective and safe in the treatment of cholestasis hepatitis(liver-gallbladder dampness-heat syndrome).

关 键 词：清疸汤 熊去氧胆酸 淤胆型肝炎 临床疗效 安全性 

分 类 号：R969.4[医药卫生—药理学] R975.5[医药卫生—药学]