降钙素原、IL-6、CRP测定在新生儿感染性疾病诊断中的临床应用价值分析  

Clinical Application Value of Procalcitonin, IL-6 and CRP in the Diagnosis of Neonatal Infectious Diseases

作　　者：傅雅琨 FU Ya-kun(Department of Neonatology,South Hospital of Fujian Provincial Hospital,Fuzhou,Fujian Province,350028 China)

机构地区：[1]福建省立医院南院新生儿科

出　　处：《中外医疗》2019年第30期38-40,共3页China & Foreign Medical Treatment

摘　　要：目的分析PCT(降钙素原)、IL-6(白细胞介素-6)、CRP(C反应蛋白)测定在新生儿感染性疾病诊断中的临床应用价值。方法纳入研究对象来自方便选取该院2017年2月—2019年2月收治的新生儿感染性疾病患者100例作为研究组,以及同期该院产科出生的100名健康新生儿作为对照组。检测并对比两组PCT、IL-6、CRP水平。将研究组100例新生儿感染性疾病患者,根据病情轻重分为A组(35例,重度感染)、B组(32例,中度感染)、C组(33例,轻度感染),对比A组、B组、C组PCT、IL-6、CRP水平。结果研究组PCT、IL-6、CRP水平分别是(11.62±3.25)μng/L、(263.84±11.51)ng/L、(12.28±2.01)mg/L;对照组分别是(1.02±0.25)μg/L、(62.05±5.14)ng/L、(3.05±0.25)mg/L。研究组显著比对照组高,差异有统计学意义(P<0.05)。A组PCT、IL-6、CRP水平分别是(16.28±2.62)μg/L、(356.28±64.25)ng/L、(17.62±3.65)mg/L;B组分别是(7.42±1.25)μg/L、(206.25±32.14)ng/L、(6.84±3.14)mg/L;C组分别是(1.05±0.25)μg/L、(63.25±2.33)ng/L、(3.16±0.21)mg/L。A组显著高于B组,B组PCT、IL-6、CRP水平显著高于C组,差异有统计学意义(P<0.05)。结论PCT、IL-6、CRP水平检测是诊断新生儿感染性疾病的重要指标,可显著提高诊断准确率,值得借鉴。Objective To analyze the clinical application value of PCT(procalcitonin),IL-6(interleukin-6)and CRP(C-reactive protein)in the diagnosis of neonatal infectious diseases.Methods One hundred patients with neonatal infectious diseases admitted to the hospital from February 2017 to February 2019 were convenient selected and enrolled as the study group,and 100 healthy newborns born in the obstetrics of our hospital were used as the control group.The levels of PCT,IL-6 and CRP in the two groups were detected and compared.100 patients with neonatal infectious diseases in the study group were divided into group A(35 cases,severe infection),group B(32 cases,moderate infection),group C(33 cases,mild infection)according to the severity of the disease,levels of PCT,IL-6 and CRP in group A,group B and group C were compared.Results The PCT,IL-6 and CRP levels in the study group were(11.62±3.25)μg/L,(263.84±11.51)ng/L,(12.28±2.01)mg/L,respectively;the control group were(1.02±0.25)μg/L,(62.05±5.14)ng/L,(3.05±0.25)mg/L.The study group was significantly higher than the control group,the difference was statistically significant(P<0.05);The PCT,IL-6 and CRP levels in group A were(16.28±2.62)μg/L,(356.28±64.25)ng/L,(17.62±3.65)mg/L,respectively;group B was(7.42±1.25)μg/L,(206.25±32.14)ng/L,(6.84±3.14)mg/L;group C was(1.05±0.25)μg/L,(63.25±2.33)ng/L,(3.16±0.21)mg/L.Group A was significantly higher than group B.The levels of PCT,IL-6 and CRP in group B were significantly higher than those in group C,the difference was statistically significant(P<0.05).Conclusion The detection of PCT,IL-6 and CRP levels is an important indicator for the diagnosis of neonatal infectious diseases,which can significantly improve the diagnostic accuracy and is worth learning.

关 键 词：降钙素原 白细胞介素-6 C反应蛋白 新生儿感染性疾病 

分 类 号：R722[医药卫生—儿科]