女性泌尿生殖道支原体感染情况及药敏结果分析  

Analysis of female urogenital tract Mycoplasma infections and drug sensitivity results

作　　者：蒋久怡 JIANG Jiuyi(Department of Clinical Laboratory of Mianyang Central Hospital,Mianyang 621000 Sichuan,China)

机构地区：[1]绵阳市中心医院检验科

出　　处：《中国民康医学》2019年第18期4-6,14,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析近3年女性患者泌尿生殖道支原体感染的分布情况及药敏结果。方法:回顾性分析2016年1月至2018年12月接受支原体检测的4259例诊断为泌尿生殖道感染和阴道炎的女性患者的临床资料,对其感染状况、年龄分布和药敏结果进行统计分析。结果:所有患者经支原体检测后,发现阳性2433例(57.13%),解脲脲原体(Uu)、人型支原体(Mh)和二者混合感染(Uu+Mh)的阳性检出率分别为47.45%、3.35%和6.22%,3年阳性检出率两两比较,差异均有统计学意义(P<0.05);Uu检出率以≤25岁的患者最高,且检出率随年龄的增长而降低,不同年龄段的检出率两两比较,差异均有统计学意义(P<0.05);Mh和Uu+Mh的检出率≤25岁最低,≥46岁最高,不同年龄段的检出率两两比较,差异亦有统计学意义(P<0.05)。患者单独感染Uu时其整体耐药性较低,对交沙霉素、克拉霉素、多西环素、米诺环素耐药性最低;患者单独感染Mh时对罗红霉素、阿奇霉素、克拉霉素的耐药性较高,对交沙霉素、多西环素、米诺环素的耐药性较低;患者发生混合感染时对罗红霉素、阿奇霉素、克拉霉素、氧氟沙星普遍耐药,对交沙霉素、多西环素、米诺环素的耐药性较低。结论:在女性泌尿生殖道感染支原体培养阳性的患者中主要以Uu感染为主,多西环素、交沙霉素和米诺环素可作为该地区女性患者支原体感染治疗的首选药物。Objective: To analyze distribution and drug sensitivity results of female urogenital tract Mycoplasma infections in the past three years. Methods: The clinical data of 4259 women diagnosed with urogenital tract infections and vaginitis through Mycoplasma detection in our hospital from January 2016 to December 2018 were retrospectively analyzed. The infection status, age distribution, and drug sensitivity results were statistically analyzed. Results: The mycoplasma detection showed that 2433 cases(57.13%) were positive, and the positive detection rates of Ureaplasma urealyticum(Uu), Mycoplasma hominis(Mh) and mixed infection(Uu+Mh) were 47.45%. 3.35% and 6.22%, and there were no statistical differences between two of them in the past three years(P<0.05). The detection rate of Uu was the highest in the patients ≤ 25 years old, and the detection rate decreased with age. The detection rate differences among different age groups were statistically significant(P<0.05). The detection rate of Mh and Uu+Mh was the lowest in the patients ≤ 25 years old, and was the highest in those ≥ 46 years old, and the detection rate differences of different age groups were statistically significant(P<0.05). The patients only with Uu infection had lower overall drug resistance and had the lowest resistance to Josamycin, Clarithromycin, Doxycycline, and Minocycline;those only with Mh infection were more resistant to Roxithromycin, Azithromycin, and Clarithromycin, and had lower resistance to Josamycin, Doxycycline, and Minocycline;and those with mixed infection were generally resistant to Roxithromycin, Azithromycin, Clarithromycin, and Ofloxacin, and had lower resistance to Josamycin, Doxycycline, and Minocycline. Conclusions: Uu infection is the main cause of female urogenital tract infections with positive Mycoplasma detection results. Doxycycline, Josamycin and Minocycline are the first-line drugs for the treatment of Mycoplasma infection in the female patients in this region.

关 键 词：支原体 感染率 耐药性 

分 类 号：R518.9[医药卫生—内科学]