儿童与成人亚急性坏死性淋巴结炎的临床特点分析  

CLINICAL FEATURES OF SUBACUTE NECROTIZING LYMPHADENITIS IN CHILDREN AND ADULTS

作　　者：李丹[1] 张冲[1] 林毅[1] 张秋业[1] LI Dan;ZHANG Chong;LIN Yi;ZHANG Qiuye(Department of Pediatrics,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院儿科

出　　处：《精准医学杂志》2019年第5期398-400,404,共4页Journal of Precision Medicine

摘　　要：目的探讨儿童与成人亚急性坏死性淋巴结炎(SNL)临床表现以及实验室指标的差异。方法对2013—2018年在我院首诊为SNL患者的临床资料进行回顾性分析,根据起病年龄将患者分为儿童组(≤16岁)和成人组(>16岁),分别进行组间临床表现及相关实验室指标的比较。结果共纳入SNL患者105例,成人组45例,儿童组60例。两组性别构成比比较,差异有统计学意义(χ^2=10.680,P<0.05)。临床表现中,儿童组发热、淋巴结压痛、皮疹患者所占比例与成人组相比,差异有统计学意义(χ^2=4.051~4.907,P<0.05);两组受累淋巴结部位、肝肿大、脾肿大等比例比较差异无统计学意义。两组患者血红蛋白降低的比例差异有统计学意义(χ^2=5.533,P<0.05);而两组血小板降低、谷丙转氨酶升高、谷草转氨酶升高、乳酸脱氢酶升高、肌酸激酶同工酶升高等指标的比例比较,差异无统计学意义(P>0.05)。结论儿童与成人SNL在临床表现及相关实验室指标方面存在相似之处,但儿童中男性多见,发热、淋巴结压痛、皮疹较成人更常见,贫血在成人中更为常见。Objective To investigate the differences in clinical manifestations and laboratory markers between children and adults with subacute necrotizing lymphadenitis(SNL).Methods A retrospective analysis was performed for the clinical data of patients who were first diagnosed with SNL in our hospital from 2013 to 2018.According to the age of onset,they were divided into children group(aged≤16 years)and adult group(aged>16 years),and clinical manifestations and related laboratory mar-kers were compared between groups.Results A total of 105 SNL patients were enrolled,with 45 patients in the adult group and 60 in the children group.There was a significant difference in sex ratio between the two groups(χ^2=10.680,P<0.05).As for cli-nical manifestations,there was a significant difference in the proportion of patients with fever,lymph node tenderness,or rash between the children group and the adult group(χ^2=4.051-4.907,P<0.05),while there were no significant differences in the site of affected lymph node and the proportion of patients with hepatomegaly or splenomegaly between the two groups.There was a significant difference in the proportion of patients with hemoglobin reduction between the two groups(χ^2=5.533,P<0.05),while there was no significant difference between the two groups in the proportion of patients with a reduction in platelet count or an increase in alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,or creatine kinase isoenzyme(P>0.05).Conclusion Children and adults with SNL have similar clinical manifestations and related laboratory markers,but in children,there is a higher proportion of male patients or patients with fever,lymph node tenderness,or rash,while anemia is more common in adults.

关 键 词：组织细胞坏死性淋巴结炎 体征和症状 血红蛋白 儿童 成年人 数据分析 

分 类 号：R551.24[医药卫生—血液循环系统疾病] R725.59[医药卫生—内科学]