含半夏中成药组方规律  

Prescription Rules of Traditional Chinese Medicine Formulae Containing Pinellia ternata

作　　者：高越[1] 刘施 黄正德[1] 胡晓雪[1] 陈树和[1] GAO Yue;LIU Shi;HUANG Zhengde;HU Xiaoxue;CHEN Shuhe(Department of Pharmacy,Hubei Provincial Hospital of TCM,Wuhan 430061,China)

机构地区：[1]湖北省中医院药事部

出　　处：《医药导报》2019年第12期1645-1651,共7页Herald of Medicine

基　　金：中药炮制技术传承基地建设项目(鄂财社发[2015]68号)

摘　　要：目的基于中医传承辅助平台(TCMISP),分析《中华人民共和国卫生部药品标准·中药成方制剂》(简称《中药成方制剂》)含半夏方剂组方规律,为临床应用及新药研发提供参考。方法运用中医传承辅助平台(V2.5)软件,对《中药成方制剂》中含半夏方剂收集整理,并构建数据库,采用关联规则、频次统计等数据挖掘方法,对疾病证候、常用药物配伍及组方规律进行分析,并对高频药对和高频证候进行深度分析。结果含半夏方剂共360首,涉及中药579味,常用药物组合49个,主治疾病17种,高频药对"半夏-陈皮""半夏-茯苓""半夏-白术",得出半夏常与理气健脾药、芳香化湿药、化痰药、消食药合用,此外,对4种高频疾病"咳嗽""积滞""喘证""眩晕"进行药物组合分析,半夏在不同组合药对中发挥作用相似。结论《中药成方制剂》中含半夏方剂多具有理气、化湿、化痰、消食之功效,用药较为集中,组方清晰;用药规律反映半夏治疗不同疾病时配伍的特点,可为充分发挥半夏方的功效以及临床科学处方提供依据。Objective To analyze the prescription rules of formulae containing Pinellia ternata in Pharmaceutical Standard of the Ministry of Health of the People’s Republic of China-Preparation of Traditional Chinese Medicine Prescription(Hereinafter referred to as Preparation of Traditional Chinese Medicine Prescription) based on Traditional Chinese Medicine Inheritance Support Platform(TCMISP). Methods Through TCMISP(V2.5), formulae containing Pinellia ternata in Preparation of Traditional Chinese Medicine Prescription were collected and organized to build the database.Data mining methods, such as frequency statistics, association rules and others, were used to analyze disease syndromes, compatibility with commonly used drugs and combination rules, and to conduct in-depth analysis of high-frequency medicine pairs and syndromes. Results There were a total of 360 prescriptions containing Pinellia ternata, involving 579 kinds of traditional Chinese medicines and 49 commonly used medicine pairs for 17 main diseases.According to the analysis for high-frequency medicine pairs of Pinellia ternate-pericarpium citri reticulatae, Pinellia ternate-Poria cocos, and Pinellia ternate-Atractylodes, Pinellia ternata is usually combined with aromatic damp-resolving drugs, apophlegmatisants, and digestant drugs to reinforce spleen and regulate the flow of Qi.In addition, according to the analysis for high-frequency diseases like cough, indigestion, asthma, megrim, Pinellia ternata has almost the same effect in different drug pairs. Conclusion The formulae containing Pinellia ternata in Preparation of Traditional Chinese Medicine Prescription have the effect of regulating Qi, reducing phlegm, resolving dampness, and promoting digestion.The results reflect the compatibility of Pinellia ternata for different diseases.The drug combinations provide theoretical basis for studying the Pinellia ternata.

关 键 词：半夏 中药成方制剂 中医传承辅助平台 组方规律 

分 类 号：R285[医药卫生—中药学]