湿润烧伤膏对高级别宫颈鳞状上皮内病变普通电刀宫颈锥形切除术后伤口转归作用的临床研究  

Effects of MEBO on the Outcome of Wound Healing after High-Grade Cervical Intraepithelial Lesion with General Electric Knife and Cervical Conization

作　　者：王慧香[1] 肖巍 潘燕[1] 初幸之[1] WANG Huixiang;XIAO Wei;PAN Yan;CHU Xingzhi(Dept.of Obstetrics and Gynecology,Beijing Tongren Hospital Affiliated to Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院妇产科

出　　处：《中国医院用药评价与分析》2019年第10期1218-1219,1223,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：首都医科大学本科生科研创新项目(No.XSKY2019192)

摘　　要：目的:探讨湿润烧伤膏对高级别宫颈鳞状上皮内病变应用普通电刀宫颈锥形切除术后伤口转归作用的临床研究。方法:选取2016年1月至2019年1月首都医科大学附属北京同仁医院拟行宫颈锥形切除术患者120例,随机分为观察组和对照组,每组60例。两组患者均于月经期结束3~7 d采用普通电刀行宫颈锥切术,观察组患者宫颈创面电凝止血后应用湿润烧伤膏;对照组患者仅行宫颈电凝止血。观察两组患者术后并发症情况、术后宫颈创面上皮化情况。结果:观察组患者的并发症总发生率为1.7%(1/60),明显低于对照组的15.0%(9/60),差异有统计学意义(P<0.05),且两组患者均无宫颈粘连发生。术后2周、1个月,观察组患者宫颈创面上皮化程度分别为(65.3±11.2)%、(89.4±5.1)%,明显高于对照组的(41.9±6.4)%、(62.5±9.6)%,差异均有统计学意义(P<0.05)。结论:湿润烧伤膏应用于普通电刀锥形切除术后创面的并发症少,宫颈愈合效果满意。OBJECTIVE:To probe into the clinical study of effects of MEBO on the outcome of wound healing after high-grade cervical intraepithelial lesion with general electric knife and cervical conization.METHODS:Totally 120 patients undergoing cervical conization admitted into Beijing Tongren Hospital Affiliated to Capital Medical University from Jan.2016 to Jan.2019 were extracted to be divided into the observation group and the control group,with 60 cases in each group.Both groups underwent cervical conization with general electric knife after 3 to 7 d of menstruation.The observation group were treated with MEBO after electrocoagulation.In the control group,only cervical electrocoagulation was performed.The postoperative complications and the postoperative skin of the cervical wound of two groups were observed.RESULTS:The total incidence of complications in the observation group was 1.7%(1/60),significantly lower than 15.0%(9/60)in the control group,with statistically significant difference(P<0.05),and no cervical adhesion occurred in two groups.At 2 weeks and 1 month after surgery,the degree of skin lesions on the cervical wounds in the observation group were(65.3±11.2)% and(89.4±5.1)%,significantly higher than that of the control group(41.9±6.4)% and(62.5±9.6)%,the difference was statistically significant(P<0.05).CONCLUSIONS:The incidence of complications of MEBO in the treatment of wound healing after high-grade cervical intraepithelial lesion with general electric knife and cervical conization is lower,and the satisfactory of cervical healing is higher.

关 键 词：美宝湿润烧伤膏 宫颈鳞状上皮内病变 普通电刀宫颈锥形切除术 

分 类 号：R932[医药卫生—生药学]