基于数据挖掘技术探讨中医治疗肺癌放疗患者的用药规律  

Research on Medication Rules of Chinese Medicine for Treatment of Patients with Lung Cancer Radiotherapy Based on Data Mining

作　　者：彭雅怡 赵东凤 严文辉[2] PENG Yayi;ZHAO Dongfeng;YAN Wenhui(Graduate School,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Brain Hospital of Hunan Province,Changsha,Hunan 410005,China)

机构地区：[1]湖南中医药大学研究生院,湖南长沙410208 [2]湖南省脑科医院,湖南长沙410005

出　　处：《湖南中医药大学学报》2019年第11期1358-1361,共4页Journal of Hunan University of Chinese Medicine

基　　金：湖南省自然科学基金项目(2018JJ6120)

摘　　要：目的探讨中医治疗肺癌放疗患者的用药规律。方法检索中国知网数据库(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed数据库公开发表的治疗肺癌放疗患者的中药处方,运用频次分析、聚类分析、关联规则分析方法对收集的处方进行数据挖掘,分析其用药规律。结果共收集到处方70张,涉及176味中药,使用频次共计890次;使用频次≥9的药物共32味;使用频次前三位的单味中药是黄芪、甘草、麦冬;使用频次前三位的药类是补虚药、清热药、化痰止咳平喘药;对32味药物进行聚类分析和关联规则分析,得出2个有效聚类群和13组药对,以补气药和滋阴药配伍为主,辅以补血活血、化痰止咳药。结论治疗肺癌放疗患者的中药处方以补益药、清热药和止咳药为主,治法以益气养阴、清肺止咳为主。Objective To explore the medication rules of traditional Chinese medicine(TCM)in treating patients with lung cancer radiotherapy.Methods TCM prescriptions published on journals for the treatment of lung cancer radiotherapy patients were searched from CNKI,Wanfang Data,VIP,CBM and PubMed.Frequency analysis,cluster analysis,and association rule analysis were used for data mining to analyze the medication rules.Results There were 70 prescriptions with 176 Chinese medicinal herbs and a total frequency of 890 times.32 Chinese medicinal herbs were used for more than 9 times,and the top 3 frequently used single herbs were Radix Astragali seu Hedysari,Radix Glycyrrhizae and Radix Ophiopogonis.The top 3 frequently used drug types were tonics for deficiency,heat-clearing medicine and medicine for resolving phlegm,relieving cough and stopping asthma.Cluster analysis and association rule analysis were performed on the 32 herbs.2 effective cluster groups and 13 drug couples were obtained.The combination of Qi-tonifying medicine and Yin-nourishing medicine were mainly used,supplemented by medicine for replenishing and activating blood and for resolving phlegm and stopping asthma.Conclusion TCM prescriptions for the treatment of lung cancer radiotherapy are mainly tonics,heat-clearing medicine and cough relieving medicine.The method of treatment mainly focused on benefiting Qi,nourishing Yin,and clearing lung heat to relieve cough.

关 键 词：数据挖掘 肺癌 放疗 中药 用药规律 

分 类 号：R256.1[医药卫生—中医内科学]