HCV与HBV共感染影响血清HBV核酸与表面抗原水平  

HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum

作　　者：张萍 刘文培 林应标[2] 代国知[2] 郭旺源[2] 江杨华[2] 唐萍 张健 瞿小旺 罗迪贤 ZHANG Ping;LIU Wenpei;LIN Yingbiao;DAI Guozhi;GUO Wangyuan;JIANG Yanghua;TANG Ping;ZHANG Jian;QU Xiaowang;LUO Dixian(Translational Medicine Institute,the First People’s Hospital of Chenzhou,University of South China,Chenzhou 423000,Hunan,China;Department of Laboratory Medicine,the First People’s Hospital of Chenzhou,Chenzhou 423000,Hunan,China)

机构地区：[1]南华大学附属郴州医院转化医学研究所,湖南郴州423000 [2]郴州市第一人民医院检验医学中心,湖南郴州423000

出　　处：《中南医学科学杂志》2019年第6期643-647,共5页Medical Science Journal of Central South China

基　　金：湖南省临床医疗技术创新引导项目(2018SK50301,2018SK50304,2018SK50308)

摘　　要：分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097,P=0.184);HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020);共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752,P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387,P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients.152 individuals with HBV infection from intravenous drug users were enrolled.52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection.Serum ALT and AST,HBsAg,HBeAg,anti-HBe,HBV DNA and anti-HCV IgG,HCV RNA were measured.The results showed that there was no significant difference in ALT and AST levels between the two groups(P=0.097,P=0.184);The positive rate of HBV DNA in the co-infection group was lower(P=0.004)compared with mono-HBV infection,and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection(P=0.020,P=0.031);there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals(r=0.752,P<0.001),but the correlation is weakened in coinfected individuals(r=0.387,P=0.042).The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion,which may indicate that HCV coinfection interfere with HBV replication.

关 键 词：乙型肝炎病毒 丙型肝炎病毒 共感染 表面抗原 病毒载量 

分 类 号：R512.6[医药卫生—内科学]