静脉预注小剂量甲氧明预防老年患者全身麻醉诱导期低血压的效果  

Effect of intravenous pre-injection of low-dose Methoxamine on preventing hypotension in elderly patients undergoing general anesthesia during induction period

作　　者：雷小华 李明 LEI Xiao-hua;LI Ming(Department of Anesthesiology,the First People′s Hospital of Fuzhou City,Jiangxi Province,Fuzhou 344000,China)

机构地区：[1]江西省抚州市第一人民医院麻醉科

出　　处：《中国当代医药》2019年第32期158-161,共4页China Modern Medicine

摘　　要：目的探讨静脉预注小剂量甲氧明预防老年患者全身麻醉诱导期低血压的效果。方法选取2017年4月~2018年4月于我院择期进行常规全身麻醉类手术的74例老年患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组各37例。两组患者术前需禁食禁水8 h,入手术室后立即开始监测血压、心电图等。观察组患者全麻诱导前静脉预注小剂量甲氧明,对照组患者同期注射等量生理盐水,两组全麻诱导期均行相同全麻诱导术。比较两组患者入室时(T1)、全麻诱导后1 min(T2)、全麻诱导后3 min/插管时(T3)、插管后3 min(T4)、插管后6 min(T5)时的血压[收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)]、心率,统计两组患者的时间指标(全麻诱导持续时间、患者清醒时间),比较两组患者的不良反应发生情况。结果两组患者T1时的血压比较,差异无统计学意义(P>0.05),T2~T5时,观察组患者的SBP、DBP、MAP均高于对照组,差异有统计学意义(P<0.05);两组患者T1~T5时的心率比较,差异无统计学意义(P>0.05);两组患者的全麻诱导持续时间、患者清醒时间比较,差异无统计学意义(P>0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05),观察组患者的低血压发生率低于对照组,差异有统计学意义(P<0.05)。结论静脉预注小剂量甲氧明能有效预防老年患者全身麻醉诱导期发生低血压。Objective To observe the effect of intravenous pre-injection of low-dose Methoxamine on preventing hypotension in elderly patients undergoing general anesthesia during induction period.Methods A total of 74 elderly patients who underwent elective routine general anesthesia surgery in the hospital from April 2017 to April 2018 were selected as study subjects.They were divided into control group and observation group by random number table method,37 cases in each group.The two groups were given fasting for solids and liquids for 8 hours before surgery.Immediately after entering operating room,blood pressure and electrocardiogram were monitored.The observation group was given intravenous pre-injection of low-dose Methoxamine before general anesthesia induction.The control group was injected with same amount of normal saline during the same period.The same general anesthesia induction was performed on both groups during general anesthesia induction period.The blood pressure(including systolic blood pressure[SBP],diastolic blood pressure[DBP],mean arterial pressure[MAP])and heart rate indexes were compared between the two groups when entering room(T1),at 1 min after general anesthesia induction(T2),at 3 min after general anesthesia induction/intubation(T3),at 3 min after intubation(T4),and at 6 min after intubation(T5).The time indexes(duration of general anesthesia induction and awake time)of patients in the two groups were statistically analyzed.The adverse reactions of the two groups were compared.Results There was no significant difference in blood pressure between the two groups at T1(P>0.05).SBP,DBP and MAP in observation group were higher than those in control group at T2 to T5,the differences were statistically significant(P<0.05).There was no significant difference in heart rate between the two groups at T1 to T5(P>0.05).There was no significant difference between the two groups in duration of general anesthesia induction or waking time(P>0.05).There was no significant difference in total incidence of adverse

关 键 词：老年 全身麻醉 诱导期 低血压 甲氧明 

分 类 号：R971.2[医药卫生—药品]