RNA甲基化在中枢神经系统作用中的研究进展  

Advances in research on the effect of RNA methylation in the central nervous system

作　　者：邓宇 杜先超 DENG Yu;DU Xianchao(Department of Environmental Health,School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学公共卫生学院环境卫生学教研室

出　　处：《沈阳医学院学报》2019年第6期489-494,499,共7页Journal of Shenyang Medical College

基　　金：国家自然科学基金(No.81302406);辽宁省高等学校基本科研项目(No.QNK201735)

摘　　要：近年来,表观转录组学成为研究热点,而其中可逆的RNA甲基化修饰引领了表观遗传修饰研究的浪潮。中枢神经系统作为人体神经系统最重要的部分,其正常的发育及功能活动是人体发育关键。研究发现RNA甲基化修饰在中枢神经系统发育过程中发挥了重要作用。本文将从RNA甲基化调节神经元、胶质细胞、神经干细胞和突触的发育等几个方面展开论述。In recent years, epitranscriptomics has become a research hotspot, and the reversible RNA methylation modification has led the wave of epigenetic modification research. The central nervous system is the most important section of nervous system as it regulates the function of various organs. Numerous studies have found that RNA methylation plays an important role in the development of the central nervous system. This review focuses on the regulation of RNA methylation in neurons, glial cells, neural stem cells(NSCs) and synaptic development.

关 键 词：表观遗传修饰 RNA甲基化 中枢神经系统 

分 类 号：Q75[生物学—分子生物学]