纳美芬在术后认知功能障碍中的应用进展  

Clinical Effect of Nalmefene on Postoperative Cognitive Dysfunction: a Literature Review

作　　者：代玲杰 袁清霞[1] DAI Lingjie;YUAN Qingxia(The Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学附属医院

出　　处：《现代医院》2019年第11期1674-1676,共3页Modern Hospitals

摘　　要：术后认知功能障碍是麻醉术后出现的大脑功能紊乱,导致意识、认知、记忆、定向等暂时性功能障碍,严重者可出现精神错乱、人格改变、谵妄等精神症状,好发于老年患者,因而备受麻醉医生的关注。纳美芬是高选择性阿片受体拮抗剂,其能竞争性的阻断内源性阿片肽对神经功能的损害作用,还能增加内源性脑保护因子的活性而达到神经保护作用,因此纳美芬在临床上常用于颅脑损伤患者的脑保护和认知功能障碍等的治疗。Postoperative cognitive dysfunction(POCD)is a brain dysfunction occurring after anesthesia,causing temporary dysfunction in consciousness,cognition,memory and orientation,etc.In severe cases,mental symptoms such as insanity,personality changes and delirium may occur.POCD are prone among elderly patients,which has aroused great attention from anesthesiologists.As a highly selective opioid receptor antagonist,nalmefene can competitively block the damage of endogenous opioid peptides on nerve function and increase the activity of endogenous brain protective factors to achieve the neuroprotective effect.Therefore,nalmefene is often clinically used for brain protection and a cure for cognitive dysfunction in patients with craniocerebral injury.

关 键 词：术后认知功能障碍 纳美芬 阿片受体拮抗剂 脑保护 

分 类 号：R979.3[医药卫生—药品] R614.206[医药卫生—药学]