早期活动性Graves眼病患者黄斑中心凹下不同脉络膜分层厚度分析  

Analysis of different choroidal stratification thickness under macular fovea in patients with early graves ophthalmopathy

作　　者：张丹 赵军[2] 张娟美[2] 田春柳 季亚男 张琳琳 Dan Zhang;Jun Zhao;Juan-Mei Zhang;Chun-Liu Tian;Ya-Nan Ji;Lin-Lin Zhang(Department of Medicine,Qingdao University,Qingdao 266000,Shandong Province,China;Department of Ophthalmology,Linyi People s Hospital,Linyi 276002,Shandong Province,China)

机构地区：[1]青岛大学医学部,山东省青岛市266000 [2]山东省临沂市人民医院眼科,276002

出　　处：《国际眼科杂志》2019年第12期2150-2152,共3页International Eye Science

摘　　要：目的:应用光学相干断层扫描增强深部成像技术比较早期活动性Graves眼病患者与健康者黄斑中心凹下不同脉络膜分层厚度的差异。方法:选取2017-12/2019-05在我院确诊的早期活动性Graves眼病患者(GO组)和年龄、性别相匹配的健康体检者各31例62眼(对照组),所有受检者均进行屈光度、最佳矫正视力(BCVA)、眼压、眼球突出度、EDI-OCT等检查,比较两组受检者黄斑中心凹下脉络膜厚度(SFCT)、脉络膜大血管层厚度(LCVT)、脉络膜毛细血管层/中血管层厚度(MCVT)的差异。结果:两组受检者等效球镜度数、BCVA、眼轴均无明显差异,但GO组受检者眼压(17.22±2.67mmHg)、眼球突出度(15.44±0.92mm)、SFCT(315.79±14.99μm)、LCVT(234.66±14.90μm)均显著高于对照组(13.35±1.54mmHg、12.90±1.00mm、239.00±12.67μm、159.16±13.30μm)(均P<0.05),而两组受检者MCVT无差异(81.13±7.46μm vs 80.13±7.63μm,P>0.05)。结论:早期活动性Graves眼病患者SFCT、LCVT增厚,MCVT无明显变化,提示应用EDI-OCT测量SFCT和LCVT对于评估早期活动性Graves眼病具有一定的参考价值。AIM:To compare the difference of choroidal delamination thickness in macular fovea between patients with early active Graves ophthalmopathy and healthy subjects by optical coherence tomography(OCT)enhanced deep imaging.METHODS:From December 2017 to May 2019,patients with early active Graves ophthalmopathy diagnosed in our hospital(GO group)and 31 patients(62 eyes)with age and sex matched healthy physical examination(control group)were selected.Diopter,best-corrected visual acuity(BCVA),intraocular pressure,exophthalmos,EDI-OCT and other examinations were performed on all the subjects.The differences of macular central concave choroidal thickness(SFCT),choroidal macrovascular layer thickness(LCVT)and choroidal capillary layer/middle vascular layer thickness(MCVT)between the two groups were compared.RESULTS:There was no significant difference in equivalent spherical lens power,BCVA and eye axis between the two groups.However,the IOP(17.22±2.67mmHg),exophthalmos(15.44±0.92mm),SFCT(315.79±14.99μm),LCVT(234.66±14.90μm)in GO group were significantly higher than those in control group(13.35±1.54mmHg,12.90±1.00mm,239.00±12.67μm,159.16±13.30μm)(all P 0x0E?Symbol|@@0x0F0.05),but there was no significant difference in MCVT between the two groups(81.13±7.46μm vs 80.13±7.63μm,P>0.05).CONCLUSION:SFCT and LCVT in patients with early active Graves ophthalmopathy are thickened,and MCVT has no obvious change,suggesting that EDI-OCT measurement of SFCT and LCVT has certain reference value for evaluating early active Graves ophthalmopathy.

关 键 词：GRAVES眼病 黄斑中心凹下脉络膜厚度 脉络膜大血管层厚度 脉络膜毛细血管层/中血管层厚度 EDI-OCT 

分 类 号：R58[医药卫生—内分泌]