低频重复经颅磁刺激对卒中后抑郁的临床疗效  

Effect of low-frequencytranscranial magnetic stimulation on the clinical efficacy of patient with post-stroke depression and the potential mechanism

作　　者：肖展宏[1] 韦宗勇 葛晓蓉 何华航 郑天晴 庞晓敏 XIAO Zhanhong;WEI Zongyong;GE Xiaorong;HE Huahang;ZHENG Tianqing;PANG Xiaomin(Department of Rehabilitation,The First People’s Hospital of Nanning,Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region 530022,China)

机构地区：[1]南宁市第一人民医院康复医学科

出　　处：《安徽医药》2019年第12期2400-2403,共4页Anhui Medical and Pharmaceutical Journal

基　　金：广西科学研究与技术开发计划项目(桂科攻14124003-6)

摘　　要：目的观察低频重复经颅磁刺激对卒中后抑郁病人抑郁状态及神经功能康复的影响。方法将纳入研究的2016年2月至2017年8月南宁市第一人民医院收治的48例卒中后抑郁病人按随机数字表法分为对照组和研究组,各24例。对照组给予常规药物及康复治疗,研究组在常规治疗基础上给予低频重复经颅磁刺激,观察两组病人治疗前后的抑郁症状的变化、神经功能评分,并检测两组病人血液中超敏C反应蛋白的表达水平。结果8周治疗过程中共退出8例病人,最终对照组19例,研究组21例。治疗前、治疗2周、4周、6周末,两组组间比较汉密尔顿抑郁量表评分和美国国立卫生研究院卒中量表总分差异无统计学意义(P>0.05);8周治疗结束后,对照组和研究组的汉密尔顿抑郁量表评分分别为(8.619±2.872)分和(11.000±2.809)分,总有效率分别为63.16%和80.95%,美国国立卫生研究院卒中量表总分分别为(8.158±2.115)分和(7.000±1.183)分,差异有统计学意义(P<0.05)。治疗前、治疗4周末,两组组间的超敏C反应蛋白含量比较差异无统计学意义(均P>0.05),治疗8周末,对照组和研究组的超敏C反应蛋白含量分别为(2.579±0.838)mg/L和(1.762±0.700)mg/L,差异有统计学意义(P<0.05)。结论低频重复经颅磁刺激可有效缓解卒中后抑郁病人的抑郁症状,促进神经功能的恢复,并降低卒中后抑郁病人血液中超敏C反应蛋白的水平。Objective To observe the effect of low frequency transcranial magnetic stimulation on the depressive state and rehabili tation of neurological function in patient with post stroke depression.Methods A randomized and controlled study was performed in 48 patients with post stroke depression from February 2016 to August 2017 in the First People’s Hospital of Nanning.Patients were randomly divided into two groups:control group and study group.Patients in the control group were given conventional neuro logical therapy and rehabilitation training,while patients in the study group were given low frequency transcranial magnetic stimula tion.The depressed emotions and neurological scores were evaluated.The expression of hypersensitive C reactive protein was also ex amined in the two groups.Results A total of 19 patients in control group and 21 patients in study group were included.Compared with the control group,no significant differences were found in the scores of HAMD and NIHSS before the treatment and the 2,4,6 weeks after treatment.After the 8 weeks of treatment,the scores of HAMD in the control group and the study group were(8.619±2.872)and(11.000±2.809),respectively,the total effective rate was 63.16%and 80.95%,respectively,and the total score of NI HSS was(8.158±2.115)and(7.000±1.183),respectively.The difference was significant(P<0.05).Before treatment,at the end of 4 weeks of treatment,there was no significant difference in the content of the hypersensitive C reactive protein between the two groups(all P>0.05).At the end of the 8 weeks of treatment,the content of hypersensitive C reactive protein in the control group and the study group was(2.579±0.838)mg/L and(1.762±0.700)mg/L,respectively.The difference was significant(P<0.05).Conclusion The low frequency repetition transcranial magnetic stimulation can effectively relieve depressive symptoms in patients with post stroke depression,promote the recovery of nervous function and reduce the level of hypersensitive C reactive protein.

关 键 词：卒中/并发症 抑郁 康复 经颅磁刺激 C反应蛋白质 治疗结果 

分 类 号：R47[医药卫生—护理学]