自体富血小板凝胶与常规换药在难治型糖尿病足中的临床疗效对比研究  

Comparative Study of Clinical Efficacy of Autologous Platelet-rich Geland Conventional Dressing Change in Refractory Diabetic Foot

作　　者：周莉莉[1] 谢文卿[1] 夏慧嫦 王运林[1] 郭春花[1] 黄秉文[1] 周砚[1] ZHOU Lili;XIE Wenqing;XIA Huichang(Second People's Hospital of Foshan Endocrinology,Guangdong Foshan 528000,China)

机构地区：[1]广东省佛山市第二人民医院内分泌科

出　　处：《河北医学》2019年第11期1891-1894,共4页Hebei Medicine

基　　金：广东省佛山市医学类科技攻关项目,(编号:0028225120516081)

摘　　要：目的:研究自体富血小板凝胶(APG)与常规换药在难治型糖尿病足(DF)中的临床疗效对比。方法:将医院2017年3月至2019年3月收治的60例难治性型DF患者随机分为观察组(标准治疗+APG,n=30)与对照组(标准治疗+常规治疗,n=30),比较两组治疗效果。结果:治疗2周、4周及8周后,两组溃疡面积均依次缩小,组间差异均显著(P<0.05),且观察组治疗2周、4周及8周后,其溃疡面积均显著小于对照组同时间水平(P<0.05);观察组治疗效果显著优于对照组(P<0.05);观察组溃疡愈合时间及住院时间均显著缩短(P<0.05);治疗过程中,观察组不良反应发生率显著低于对照组(P<0.05)。结论:APG联合标准治疗能有效提高难治型DF患者溃疡愈合效果。Objective:To compare the clinical efficacy of autologous platelet-rich gel(APG)and conventional dressing change in refractory diabetic foot(DF).Methods:60 patients with refractory DF admitted to hospital from March 2017 to March 2019 were randomly divided into observation group(standard treatment+APG,n=30)and control group(standard treatment+conventional treatment,n=30).The treatment effects were compared between the two groups.Results:After 2 weeks,4 weeks and 8 weeks of treatment,the ulcer area in the two groups was decreased in turn,and the difference between the two groups was significant(P<0.05),and the ulcer area in observation group after 2 weeks,4 weeks and 8 weeks of treatment was smaller than that in control group(P<0.05).The treatment effects in observation group were significantly better than those in control group(P<0.05).The ulcer healing time and hospital stay in observation group were significantly shorter than those in control group(P<0.05).During treatment,the incidence rate of adverse reactions in observation group was significantly lower than that in control group(P<0.05).Conclusion:APG combined with standard therapy can effectively improve the healing effect of ulcer in refractory DF patients.

关 键 词：难治型糖尿病足 自体富血小板凝胶 常规换药 临床疗效 

分 类 号：R47[医药卫生—护理学]