纸基微流控样品预富集技术与应用研究进展  

Research and Application Progress of Paper-based Microfluidic Sample Preconcentration

作　　者：梁斯佳 毛基锴 龚晨[1] 于东冬 周建光[1] LIANG Si-Jia;MAO Ji-Kai;GONG Chen;YU Dong-Dong;ZHOU Jian-Guang((Research Center for Analytical Instrumentation,Institute of Cyber-Systems and Control,State Key Laboratory of Industrial Control Technology,Zhejiang University,Hangzhou 310027,China;Department of Chemistry,Zhejiang University,Hangzhou 310027,China;Hospital of Zhejiang University,Zhejiang University,Hangzhou 310000,China)

机构地区：[1]浙江大学工业控制技术国家重点实验室智能系统与控制研究所分析仪器研究中心,杭州310027 [2]浙江大学化学系,杭州310027 [3]浙江大学校医院,杭州310000

出　　处：《分析化学》2019年第12期1878-1886,共9页Chinese Journal of Analytical Chemistry

基　　金：国家重点研发计划项目(No.2016YFC0800905);浙江省重点研发计划项目(No.2018C03G2011156)资助~~

摘　　要：样品预处理是分析检测的重要环节,尤其对于原始浓度低的样品,预富集技术有利于提高分析方法的准确度,拓展应用范围。但是,常规样品预富集技术往往操作繁琐,且依赖昂贵设备,检测时间和成本随之增加。纸基微流控样品预富集技术具有易制备、低成本、高效率等优点,简化了操作过程,降低了检测成本。本文重点介绍了近年来纸基微流控样品预富集技术与应用的研究进展,包括富集原理、纸基材料选择与装置结构设计及应用,并对此技术的发展趋势进行了展望。Sample pretreatment is a key link in the whole process of analysis and detection. For samples whose original concentration is lower than the detection limit of analytical method, pre concentration technology is necessary, which is beneficial to improve the accuracy of the analytical method and expand the application range. However, conventional sample pre concentration technology is often cumbersome and depends on expensive equipment, resulting in the increased inspection time and cost. The paper-based microfluidic sample pre concentration technology is favored by domestic and foreign scholars for its easy preparation, low cost and high efficiency. This technology simplifies the operation process and reduces the detection cost. This paper focuses on the research and application progress of paper-based microfluidic sample preconcentration in recent years, including enrichment principle, paper-based material selection and device structure design, and the application of this technology. Finally, the development trend of this technology is prospected.

关 键 词：纸基微流控 样品预富集 动电堆叠 评述 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]