经门静脉自体骨髓细胞回输治疗失代偿期肝硬化42例疗效分析  

Analysis of clinical effect of auto-marrow cells reinfusion through portal vein in treatment of 42 patients with decompensated liver cirrhosis

作　　者：张景春[1] 赵向宁[1] 刘保池[2] Zhang Jingchun;Zhao Xiangning;Liu Baochi(The Second Affiliated Hospital of Henan University of Science and Technology,Depta.of Hepatobiliary Surgery,Luoyang Henan 471000,China;Shanghai Public Health Clinical Center,Depa.of General Surgery,Shanghai 201508,China)

机构地区：[1]河南科技大学第二附属医院肝胆外科,洛阳471000 [2]上海市公共卫生临床中心普外科,上海201508

出　　处：《河南外科学杂志》2019年第6期13-15,共3页Henan Journal of Surgery

摘　　要：目的观察经门静脉自体骨髓细胞回输治疗失代偿期肝硬化患者的效果及安全性。方法回顾分析42例接受经门静脉输液港途径回输自体骨髓细胞治疗的失代偿期肝硬化患者的临床资料。比较患者术前、术后连续3个月血清丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、清蛋白(ALB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及临床症状、腹部体征改善情况。结果除1例患者术后因肝性脑病加重死亡外,其余患者自体骨髓细胞回输术后1个月及3个月的ALT、TBIL、ALB、PT、APTT均较术前改善,差异有统计学意义(P<0.05)。自体骨髓细胞回输术后3个月,患者乏力好转30例,食欲改善32例,腹胀减轻29例,腹腔积液减少25例。未发现严重不良反应及并发症。结论经门静脉自体骨髓细胞回输治疗失代偿期肝硬化患者疗效确切、安全性好。Objective To observe the effect and safety of autologous bone marrow cell infusion via portal vein in the treatment of decompensated liver cirrhosis.Methods The clinical data of 42 patients with decompensated liver cirrhosis treated by infusion of autologous bone marrow cells via portal vein infusion port were analyzed retrospectively.the clinical data of 42 patients with decompensated liver cirrhosis were analyzed.The clinical symptoms and abdominal signs of serum alanine aminotransferase(ALT),total bilirubin(TBIL),albumin(ALB),(ALB),activated partial thromboplastin time(APTT),clinical symptoms and abdominal signs were compared before and 3 months after operation.Results Except for one patient who died of hepatic encephalopathy after operation,the ALT,TBIL,ALB,PT,APTT of the other patients at 1 month and 3 months after autologous bone marrow cell infusion was significantly improved compared with that before operation(P<0.05).Three months after autologous bone marrow cell infusion,fatigue was improved in 30 cases,appetite was improved in 32 cases,abdominal distension was reduced in 29 cases,and abdominal fluid accumulation was reduced in 25 cases.No serious adverse reactions and complications were found.Conclusion Portal vein autologous bone marrow cell infusion is effective and safe in the treatment of decompensated liver cirrhosis.

关 键 词：失代偿期肝硬化 自体骨髓细胞 门静脉 肝功能 

分 类 号：R657.31[医药卫生—外科学]