P2X7受体参与疼痛调节机制的研究进展  

Research progress of P2X7 receptors involved in pain regulation

作　　者：陆帆 傅燕璐 高银平 刘荣君 陈晓薇 LU Fan;FU Yan-lu;GAO Yin-ping;LIU Rong-jun;CHEN Xiao-wei(Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo Key Laboratory of Behavioral Neuroscience,the Medical School of Ningbo University,Ningbo Zhejiang 315211,China)

机构地区：[1]宁波大学医学院浙江省病理生理学技术研究重点实验室宁波行为学重点实验室

出　　处：《中国药理学通报》2019年第12期1629-1633,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金(No 81671089);浙江省病理生理学技术研究重点实验室开放基金资助(No 201808);浙江省自然科学基金(No LY19H090004);宁波市自然科学基金(No 2018A610304)

摘　　要：ATP门控离子通道受体P2X7受体近年来被广泛关注。P2X7受体受ATP及其衍生物激活后,诱导一系列反应如PANX1的激活和IL-1β的释放。阐明P2X7受体在疼痛中的作用及机制,为新型高效镇痛药物的研发提供思路。该文从炎性痛、神经病理痛、癌痛和吗啡镇痛耐受等方面阐述P2X7受体在疼痛中的研究进展,并探讨P2X7受体参与疼痛调节过程的可能机制。The ATP-gated ionotropic P2X7 receptor has been widely concerned in recent years.Upon activation by ATP and its derivatives,P2X7 receptor induces a series of responses such as activation of PANX1 and release of IL-1β.Elucidation of the role and mechanism of P2X7 receptor in pain would provide ideas for the development of new and effective analgesic drugs.This review discusses the recent progress of P2X7 receptor in inflammatory pain,neuropathic pain,cancer pain,and morphine tolerance,and summarizes the possible mechanism of P2X7 receptor involved in the modulation of pain.

关 键 词：P2X7受体 疼痛 吗啡耐受 单核苷酸多态性 PANX1 炎症 突触传递 

分 类 号：R392.11[医药卫生—免疫学] R364.5[医药卫生—基础医学]