主要抗生素的太赫兹光谱检测与分析研究进展  

Progress on Terahertz Spectroscopic Detection and Analysis on Antibiotics

作　　者：李斌[1] 赵旭婷 张永珍 陈怡每 LI Bin;ZHAO Xu-ting;ZHANG Yong-zhen;CHEN Yi-mei(Beijing Research Center for Information Technology in Agriculture,Beijing 100097,China)

机构地区：[1]北京农业信息技术研究中心

出　　处：《光谱学与光谱分析》2019年第12期3659-3666,共8页Spectroscopy and Spectral Analysis

基　　金：北京市农林科学院创新能力建设专项(KJCX20180421);国家自然科学基金项目(61601034);动物营养学国家重点实验室开放课题(2004DA125184F1723)资助

摘　　要：抗生素具有治疗各种细菌感染或致病微生物感染类疾病的作用,获得主要抗生素的吸收特性可对抗生素添加进行有效的定性定量监测和控制,在医药、畜牧和水产业等领域都有重要意义和使用价值。太赫兹光谱技术作为一种无损、高效、便捷的新型光谱探测技术,在国防安全、信息通信、材料、环境生物医学、农业和食品安全等领域有良好的应用前景。文章介绍了太赫兹时域光谱技术(THz-TDS)检测系统的组成结构和工作原理,综述了现阶段太赫兹时域光谱技术在常用抗生素方面检测与分析的主要研究进展,重点归纳了β-内酞胺类、氨基糖苷类、四环素类、喹诺酮类、大环内脂类和磺胺类等主要抗生素的太赫兹定性识别与定量分析研究,给出了太赫兹时域光谱技术在主要抗生素检测方面的研究潜力和存在问题,为太赫兹技术未来用于主要抗生素定性定量快速检测仪器设备研发提供参考。Antibiotics have the property of treating various bacterial infections and pathogenic microorganisms.The absorption spectrum of antibiotics for detection can effectively monitor and control its addition,which is of important significance and value in the fields of medicine,animal husbandry and aquaculture et al.Terahertz time-domain spectroscopy(THz-TDS)is a brand-new spectrum detection tool featuring being non-destructive,high-efficient and convenient,which owns great application potentials and bright prospects in many fields such as national defense security,information communication,materials,environment,biomedicine,agriculture and food safety.This paper introduced the structure and working principle of the terahertz time-domain spectroscopy detection system,and summarized the research progress of terahertz time-domain spectroscopy on antibiotics detection.The identification and quantitative analysis methods on main antibiotics such asβ-indoleamines,aminoglycosides and tetracycline,quinolones,macrolides,sulfonamides,etc.were induced.The development trend and unsolved problems of terahertz time-domain spectroscopy on antibiotics detection were then presented,which provides a reference for future development of qualitative and quantitative rapid detection instruments.

关 键 词：太赫兹时域光谱 抗生素 吸收系数 折射率 

分 类 号：O657.3[理学—分析化学]