自拟鼻炎方治疗过敏性鼻炎的疗效观察  

The effect of self-designed TCM formula on treating allergic rhinitis

作　　者：张文芳 田爱平[1] ZHANG Wen-fang;TIAN Ai-ping(Cangzhou Hospital of Integrated Traditional and Western Medicine,Cangzhou Hebei 061001)

机构地区：[1]沧州中西医结合医院

出　　处：《世界中西医结合杂志》2019年第11期1591-1595,共5页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察自拟鼻炎1、2号方联合西药治疗对于过敏性鼻炎患者的治疗效果及其对生活质量、鼻腔局部炎症的影响。同时了解此种疗法对于疾病复发方面的干预作用。方法将87例过敏性鼻炎患者随机分为治疗组和对照组。对照组给予鼻吸入激素、氯雷他定治疗,治疗组在上述治疗的基础上给予中药口服,两组疗程均为4周。观察两组患者治疗结束时的疾病控制率,治疗过程中及结束后的鼻炎症状评分、生活质量评分、鼻灌洗液嗜酸性粒细胞阳离子蛋白(ECP)水平。同时评估治疗结束后2个月内疾病复发情况。结果治疗组总有效率95.5%,对照组总有效率81.4%,两组比较差异有统计学意义(P<0.05)。经过2周的治疗之后治疗组及对照组四项症状积分均较治疗前有了明显改善(P<0.05),其中治疗组鼻涕症状的改善优于对照组(P<0.05);治疗结束时两组患者的四项症状积分再次出现进一步改善的趋势(P<0.05);治疗组在鼻涕、喷嚏及鼻痒症状方面积分优于对照组(P<0.05);在治疗结束后2个月,治疗组在鼻涕、喷嚏症状方面积分仍占优(P<0.05)。治疗2周后两组各项评分及总分均较治疗前有明显改善(P<0.05),其中治疗组在鼻部症状、睡眠、日常活动、情感反应及总分方面优于对照组(P<0.05);治疗结束时两组RQLQ评分进一步出现明显下降(P<0.05),且治疗组明显优于对照组(包括各项目评分及总分)(P<0.05);在治疗结束后2个月治疗组仍在鼻部症状、行为、日常活动及总分方面显示出优势(P<0.05)。在治疗结束2个月后,治疗组1例复发患者,复发率2.27%,对照组6例复发患者,复发率13.95%,两组比较差异有统计学意义(P<0.05)。治疗结束时两组ECP水平均较治疗前有了明显下降(P<0.05),且治疗组优于对照组(P<0.05);2个月后对照组ECP有所回升,但治疗组仍维持于低水平,且优于对照组(P<0.05)。结论在中医辨证施治基础上联合西�Objective To observe the effect of self-designed TCM formula(No.1 and No.2)combined with western medicine on allergic rhinitis and its influence on quality of life,inflammation in nasal cavity and recurrence.Methods 87 patients with allergic rhinitis were randomly divided into the treatment group and the control group.The control group was given intranasal inhaled corticosteroid and loratadine tablets,and the treatment group was given TCM medicinals orally for 4 weeks.Disease control rate(DCR),rhinitis symptom score,quality of life score(QOL),ECP level during and after the treatment were compared and recurrence rate was evaluated 2 months after the treatment.Results The total effective rate was 95.5%in the treatment group and 81.4%in the control group,with significant differences(P<0.05).After 2 weeks′treatment,four symptom scores in both groups improved significantly(P<0.05),and the improvement of nasal discharge in the treatment group was greater than the control group(P<0.05).After treatment,four-symptom scores further improved in both groups(P<0.05);symptom scores of nasal discharge,sternutation and rhinocnesmus in the treatment group were better than those of the control group(P<0.05);2 months after the treatment,the scores of nasal discharge and sternutation were still better than the control group(P<0.05).After 2 weeks′treatment,each symptom score and the total score in both groups were improved significantly(P<0.05),and nasal symptoms,sleeping,daily activities,emotional response and the total score in the treatment group were better than those in the control group(P<0.05);after treatment,RQLQ scores in both groups decreased significantly(P<0.05)and the scores in the treatment group were better than the control group,with significance(single scores and total score)(P<0.05);2 months after the treatment,nasal symptoms,behavior,daily activities and the total score in the treatment group were better than the control group(P<0.05).2 months after the treatment,the recurrence rate was 2.27%in the treatment gr

关 键 词：中药 过敏性鼻炎 鼻鼽 生活质量 炎症 复发 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]