血塞通注射液治疗2型糖尿病并无症状性心肌缺血的疗效观察  

Efficacy of Xuesaitong Injection in the treatment of type 2 diabetes mellitus with asymptomatic myocardial ischemia

作　　者：申林[1] 杜文华[2] 贾李蓉 范强 SHEN Lin;DU Wen-hua;JIA Li-rong;FAN Qiang(Huilongguan Community Health Service Center,Changping District,Beijing 100096;Changping District Hospital of Integrated Traditional Chinese and Western Medicine of Beijing,Beijing 102208;China Academy of Chinese Medical Sciences,Beijing 100700;Wuhan Huangpi District Chinese Medicine Hospital,Wuhan Hubei 430000)

机构地区：[1]北京市昌平区回龙观社区卫生服务中心,北京100096 [2]北京市昌平区中西医结合医院,北京102208 [3]中国中医科学院,北京100700 [4]武汉市黄陂区中医医院,湖北武汉430000

出　　处：《世界中西医结合杂志》2019年第11期1609-1611,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(81560764)

摘　　要：目的观察血塞通注射液治疗2型糖尿病并无症状性心肌缺血的临床疗效。方法选取2017年1月至2018年6月住院2型糖尿病并无症状性心肌缺血患者60例,随机分为治疗组和对照组,每组30例,两组患者均进行饮食控制和胰岛素治疗(门冬胰岛素30 R,住院观察期间注射剂量为早14 U晚12 U),保证血糖控制平稳,其中治疗组在此治疗的基础上加用血塞通注射液300 mg+0.9%氯化钠注射液250 ml静脉滴注,1次/d,对照组给予复方丹参注射液12 ml+0.9%氯化钠注射液250 ml静脉滴注,1次/d。两组患者均治疗4周后,比较治疗前后两组患者白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、细胞间黏附分子-1(ICAM-1)及24 h动态心电图。结果治疗后与对照组比较,治疗组有效率86.7%明显高于对照组53.3%,差异有统计学意义(P<0.05)。治疗后两组患者IL-1β、TNF-a、ICAM-1水平与治疗前比较均呈下降趋势(P<0.05),且与对照组比较,治疗组下降更明显,差异有统计学意义(P<0.05)。治疗后两组患者ST段压低次数、ST段持续总时间、心肌缺血总负荷与治疗前比较均呈下降趋势(P<0.05),且与对照组比较,治疗组下降更明显,差异有统计学意义(P<0.05)。结论血塞通注射液可明显降低2型糖尿病心肌病无症状性心肌缺血患者炎症因子水平,改善心肌缺血程度,改善患者心功能。Objective To observe the clinical efficacy of Xuesaitong Injection in the treatment of type 2 diabetes mellitus with asymptomatic myocardial ischemia.Methods 60 patients with type 2 diabetes mellitus and asymptomatic myocardial ischemia admitted from January 2017 to June 2018 were randomly divided into the treatment group and the control group,with 30 cases in each group.Diet control and insulin treatment was given to all the patients(insulin aspart 30 R,14 U in the morning and 12 U in the evening during observation)to control the blood glucose level.The treatment group was given Xuesaitong Injection 300 mg+0.9%sodium chloride injection 250 ml intravenous drip,once a day;and the control group was given Compound Danshen Injection 12 ml+0.9%sodium chloride injection 250 ml intravenous drip,once a day.IL-1β,TNF-α,ICAM-1 and 24 h DCG of the two groups were compared before and after treatment.Results The effective rate of the treatment group was 86.7%,which was significantly higher than that(53.3%)of the control group(P<0.05).The levels of IL-1β,TNF-αand ICAM-1 in both groups decreased after the treatment(P<0.05).Compared with the control group,the decrease of the treatment group was significant(P<0.05).After treatment,the number of ST-segment depression,ST-segment total duration,and total myocardial ischemia burden in both groups decreased(P<0.05).Compared with the control group,the treatment group decreased more significantly with statistical significance(P<0.05).Conclusion Xuesaitong Injection can significantly reduce the level of inflammatory factors in patients with type 2 diabetes mellitus with asymptomatic myocardial ischemia,improve myocardial ischemia and cardiac function.

关 键 词：血塞通注射液 糖尿病心肌病 心肌缺血 炎症因子 

分 类 号：R587.1[医药卫生—内分泌]