复方芪麻胶囊干预高血压病患者血压、血脂自身对照研究Meta分析  

Meta-analysis of the self-controlled study on intervention of compound Qima capsule on blood pressure and blood lipid in patients with hypertension

作　　者：赵自明 夏能能 任薇 Zhao Ziming;Xia Nengneng;Ren Wei

机构地区：[1]广东省中医药工程技术研究院/广东省中医药研究开发重点实验室

出　　处：《中医临床研究》2019年第30期18-24,共7页Clinical Journal Of Chinese Medicine

摘　　要：目的:系统评价复方芪麻胶囊(QM)干预前后高血压病患者血压、血脂的变化。方法:检索并筛选2018年7月31日前中国知网(CNKI)、万方和维普(VIP)三大中文全文数据库中收录的有关QM干预高血压患者血压和血脂的自身对照或自身对照+随机对照研究的全文文献。评价文献质量并提取基线资料(年龄、性别、病程、血压分级)、研究设计(处理因素、剂量、疗程)、样本量和效应指标(均值、标准差、频数)数据信息后,由RevMan 5.3软件先进行异质性分析,采用Z检验进行组间效应比较。结果:共收录28篇文献,收治967例高血压病患者;与治疗前比较,QM治疗后高血压病患者收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、总甘油三酯(TG)较治疗前均有显著性降低(P<0.01),而高密度脂蛋白(HDL)有显著性升高(P>0.05)。结论:QM单独或合用降压西药具有降压和调脂效应,可用于高血压病的临床治疗。Objective:To evaluate anti-hypertensive and anti-hyperlipidemic effects of Compound Qima Capsule(QM)in hypertension patients by meta analysis.Methods:The full-text literatures about QM intervention on blood pressure and blood lipid in hypertension patients were searched and screened from the three major full-text databases of Chinese periodicals,i.e.CNKI,Wanfang and Weipu(VIP),published before July 31,2018.After evaluating the literature quality and extracting data information,heterogeneity analysis was performed by using RevMan 5.3 software,and then Z-test was used to compare the inter-group effects.Results:28 literatures were collected and 967 hypertension patients were treated.After treatment,SBP,DBP,TG and TG were significantly lower than those before treatments(P<0.01),while HDL was significantly higher(P<0.01).Conclusion:QM alone or combined with anti-hypertensive western medicines can both lower blood pressure and regulate lipid,and it is suitable for clinical use for hypertension patients.

关 键 词：高血压病 复方芪麻胶囊 降血压 调血脂 META分析 

分 类 号：R544.1[医药卫生—心血管疾病]