小儿豉翘清热颗粒治疗疱疹性咽峡炎疗效研究  

Study on efficacy of child Chiqiao Qingre granules in the treatment of herpangina

作　　者：李晓冬 LI Xiao-dong(Dalian Women and Children’s Medical Center,Dalian 116021,China)

机构地区：[1]大连市妇女儿童医疗中心

出　　处：《中国现代药物应用》2019年第23期108-109,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨小儿豉翘清热颗粒治疗疱疹性咽峡炎的疗效。方法 100例疱疹性咽峡炎患儿,随机分为观察组和对照组,各50例。对照组患儿给予利巴韦林颗粒治疗,观察组患儿在对照组的基础上给予小儿豉翘清热颗粒治疗。比较两组患儿的治疗效果、症状缓解时间、不良反应发生情况、治疗前后的炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、脂联素(APN)]、免疫因子[CD3^+、CD4^+、CD4^+/CD8^+]水平。结果观察组总有效率96%高于对照组的80%,差异具有统计学意义(χ^2=6.0606, P<0.05)。观察组退热时间、止咳时间、咽痛消失时间分别为(1.32±0.51)、(3.15±1.19)、(3.62±1.18)d,对照组退热时间、止咳时间、咽痛消失时间分别为(3.15±0.55)、(5.15±1.32)、(5.32±1.53)d。观察组退热时间、止咳时间、咽痛消失时间均短于对照组,差异均具有统计学意义(t=17.2519、7.9575、6.2214, P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^2=0.2105,P>0.05)。治疗前,两组患儿的IL-6、TNF-α、hs-CRP、APN、CD3^+、CD4^+、CD4^+/CD8^+水平比较,差异均无统计学意义(P>0.05);治疗后,观察组IL-6、TNF-α、hs-CRP、APN、CD3^+、CD4^+、CD4^+/CD8^+水平均优于对照组,差异具均有统计学意义(P<0.05)。结论小儿豉翘清热颗粒应用于疱疹性咽峡炎的治疗中,效果确切,不良反应少,值得在小儿疱疹性咽颊炎治疗中应用、推广。Objective To discuss the efficacy of child Chiqiao Qingre granules in the treatment of herpangina. Methods A total of 100 children with herpangina were randomly divided into observation group and control group, with 50 cases in each group. The control group was treated by ribavirin granules, and the observation group was treated by child Chiqiao Qingre granules on the basis of the control group. Comparison was made on therapeutic effect, symptom remission time, occurrence of adverse reactions, inflammatory factors [interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive C-reactive protein(hs-CRP), adiponectin], and immune factors [CD3+, CD4+, CD4+/CD8+] before and after treatment between the two groups. Results The total effective rate 96% in the observation group was higher than 80% in the control group, and the difference was statistically significant(χ2=6.0606, P<0.05). The body temperature recovery time, cough relief time and pharyngalgia disappearance time were(1.32±0.51),(3.15±1.19) and(3.62±1.18) d in the observation group, which were(3.15±0.55),(5.15±1.32) and(5.32±1.53) d in the control group. The body temperature recovery time, cough relief time and pharyngalgia disappearance time in the observation group was shorter than those in the control group, and their difference was statistically significant(t=17.2519, 7.9575, 6.2214, P<0.05). There was no statistically significant difference in incidence of adverse reactions between the two groups(χ2=0.2105, P>0.05). Before treatment, both groups had no statistically significant in levels of IL-6, TNF-α, hs-CRP, APN, CD3+, CD4+ and CD4+/CD8+(P>0.05). After treatment, the levels of IL-6, TNF-α, hs-CRP, APN, CD3+, CD4+and CD4+/CD8+ in observation group was better than those in the control group, and the difference was statistically significant(P<0.05). Conclusion Child Chiqiao Qingre granules shows affirmative effect in the treatment of herpangina, and the adverse reactions is less. It is worthy of promotion and application in the treatmen

关 键 词：小儿豉翘清热颗粒 疱疹性咽峡炎 利巴韦林颗粒 

分 类 号：R72[医药卫生—儿科]