口腔颌面外科围手术期抗菌药物应用的合理性分析  

Rational analysis of the application of antibiotics in the perioperative period of oral and maxillofacial surgery

作　　者：陈昀霞 邹锋[2] CHEN Yun-xia;ZOU Feng(Department of Pharmacy,Changzhou Stomatological Hospital,Changzhou 213003,China)

机构地区：[1]常州市口腔医院药剂科,213003 [2]常州市口腔医院颌面外科,213003

出　　处：《中国现代药物应用》2019年第23期211-213,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析口腔颌面外科围手术期抗菌药物应用的合理性。方法选择2018年1~12月本院进行口腔颌面外科手术的338例患者作为研究对象,分析围手术期抗菌药物应用合理性。结果 338例患者中有20例患者没有使用抗菌药物,头孢菌素类、林可酰胺类及硝基咪唑类构成比分别为51.45%、3.39%及45.16%。318例使用抗菌药物的患者中使用1种抗菌药物的50例(15.72%),其中45例(14.15%)为口服给药, 5例(1.57%)为静脉输注给药;2种药物联用的245例(77.04%),其中158例(49.69%)为口服给药, 87例(27.36%)为静脉输注给药;3种及4种药物联用均为序贯疗法,分别为12例(3.77%)和11例(3.46%)。318例患者有303例抗菌药物使用不合理;其中9例联合用药不合理,10例给予剂量不合理, 16例给药频次不合理, 61例给药方式不合理, 177例给药时机不合理, 30例术后用药时间过长。结论联合用药不合理、给予剂量不合理、给药频次不合理、术前用药时机和方式不当及术后用药时间过长是口腔颌面外科围手术期抗菌药物应用不合理的主要原因。Objective To analyze the rationality of antibiotics in the perioperative period of oral and maxillofacial surgery. Methods A total of 338 patients with oral and maxillofacial surgery as study subjects, and their rationality of antibiotics in the perioperative period was analyzed. Results Among 338 patients, 20 patients did not use antibiotics, and the composition ratios of cephalosporins, lincosamides and nitroimidazoles were 51.45%, 3.39% and 45.16%, respectively. Among 318 patients who used antibiotics, 50 cases(15.72%) used 1 kind of antibiotics, of which 45 cases(14.15%) were given orally and 5 cases(1.57%) were given intravenously;245 cases(77.04%) were combined with the 2 kinds of antibiotics, of which 158 cases(49.69%) were given orally and 87 cases(27.36%) were given intravenously;the combination of 3 and 4 kinds of antibiotics was sequential therapy, with 12 cases(3.77%) and 11 cases(3.46%) respectively. Among 318 cases, 303 cases were irrational in the use of antibiotics, of which 9 cases were irrational in combination, 10 cases in dosage, 16 cases in frequency of medication, 61 cases in mode of medication, 177 cases in timing of medication and 30 cases in long medication time after operation. Conclusion The main reasons for the irrational use of antibiotics in the perioperative period of oral and maxillofacial surgery are the irrational combination of drugs, the irrational dosage, the unreasonable frequency of medication, the improper timing and method of medication after operation and the long time medication after operation.

关 键 词：口腔颌面外科 围手术期 抗菌药物 合理性 

分 类 号：R47[医药卫生—护理学]