氨基酸修饰β-环糊精对胆酸分子键合的热力学性质及生物应用  

Binding thermodynamics of amino acid modified β-cyclodextrins with bile salts and their biological applications

作　　者：王倩 柳志学 张瀛溟[2] 刘育[2,3] Qian Wang;Zhixue Liu;Ying-Ming Zhang;Yu Liu(School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China;College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China;Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300072,China)

机构地区：[1]天津商业大学生物技术与食品科学学院,天津300134 [2]南开大学化学系,元素有机化学国家重点实验室,天津300071 [3]天津化学化工协同创新中心,天津300072

出　　处：《中国科学：化学》2019年第11期1343-1350,共8页SCIENTIA SINICA Chimica

基　　金：天津市教委项目(编号:160021);天津市自然科学基金(编号:18JCQNJC76400);国家自然科学基金(编号:21432004,21772099,21861132001)资助项目

摘　　要：环糊精对客体分子的选择键合是当今超分子化学的研究热点之一.其中,环糊精衍生物对胆酸类分子的键合行为及热力学性质研究对于理解主-客体识别机理及热力学起源具有重要的科学意义.本文主要综述了甘氨基、色氨酸、酪氨酸及其脱羧衍生物修饰的β-环糊精对几种典型胆酸分子的识别,包括胆酸(CA)、脱氧胆酸(DCA)、鹅去氧胆酸(CDCA)、甘胆酸(GCA)及牛黄胆酸(TCA)的键合模式、键合能力、分子选择性以及热力学起源,尤其是在清除体内胆酸、调控胆酸平衡、治疗疾病方面的应用.这些研究对于进一步深入理解主客体相互作用的识别机理以及推动超分子化学的发展都具有重要的作用.Selective binding of cyclodextrins(CDs) with guests has become one of the research hotspots in modern supramolecular chemistry. Investigation on the binding behaviors and thermodynamics of CD derivatives to bile acids is of great scientific significance for understanding the host-guest recognition mechanism and thermodynamic origins.Thus, this review will focus on the binding mode, binding ability, molecular selectivity and binding thermodynamics of glycine, tryptophan, tyrosine and its decarboxylated derivatives modified CDs with a series of bile acid guests, i.e.,cholate(CA), deoxycholate(DCA), chenodeoxycholate(CDCA), glycocholate(GCA) and taurocholate(TCA), as well as their potential applications in the clearance of bile acids in human body, regulation of the bile acids balance, treatment of diseases, which will facilitate the molecular-level understanding of the molecular recognition mechanism and eventually promote the development of supramolecular chemistry.

关 键 词：环糊精 胆酸 分子识别 热力学性质 生物应用 

分 类 号：R28[医药卫生—中药学]