肥胖导致男性不育的表观遗传机制研究进展  

Epigenetic mechanism of obesity-induced male infertility

作　　者：王翠艳(综述) 刘红英(审校)[2] WANG Cui-yan;LIU Hong-ying(School of Bioscience and Technology,Weifang Medical College,Weifang,Shandong 261000,China;Teaching Group of Genetics,Weifang Medical College,Weifang,Shandong 261000,China)

机构地区：[1]潍坊医学院生物科学与技术学院,山东潍坊261000 [2]潍坊医学院遗传教研组,山东潍坊261000

出　　处：《中华男科学杂志》2019年第11期1036-1039,共4页National Journal of Andrology

摘　　要：肥胖引发表观遗传改变可导致男性出现不育表型。关于肥胖与男性不育的关系问题,早期研究多集中于内分泌方面。近年研究发现肥胖还可以引发机体表观遗传改变,如DNA甲基化,残余组蛋白修饰,小RNA等,影响精子成熟发育。DNA甲基化是胞嘧啶-磷酸-鸟嘌呤二核苷酸的胞嘧啶残基上的调节标记,肥胖导致DNA甲基化异常,并改变mRNA表达丰度,还可以影响印记基因表达出现印记基因病。残余组蛋白修饰方式包括甲基化、乙酰化等,它们可以相互作用或协同作用,以保证精子正常生长发育。肥胖可以改变甲基化酶及乙酰化酶活性,直接影响残余组蛋白的甲基化和乙酰化;还可以影响精子小RNA的表达,导致精子缺陷。本文就肥胖引起的表观遗传学改变及导致男性不育的作用机制做逐一综述。Epigenetic changes induced by obesity can lead to male infertility phenotype.As for the relationship between obesity and male infertility,early studies mostly focused on the endocrine aspect.Recent studies have found that obesity can cause epigenetic changes,such as DNA methylation,residual histone modification,small RNA,etc,affecting sperm maturation and development.DNA methylation is a regulatory marker on cytosine residue of cytosine-phosphate-guanine dinucleotide.Obesity leads to abnormal DNA methylation,changes mRNA expression abundance,affects imprinted gene expression induses imprinted gene diseases.The modification methods of residual histones include methylation,acetylation,etc.They can interact or cooperate to ensure the normal growth and development of sperm.Obesity changes methylase and acetylase activities and directly affects methylation and acetylation of residual histones,and the expression of micro-RNAs in sperm as well,consequently causing sperm defects.This article reviews epigenetic changes caused by obesity and the mechanism of male infertility.

关 键 词：肥胖 男性不育 表观遗传 DNA甲基化 组蛋白修饰 小RNA 

分 类 号：R698.2[医药卫生—泌尿科学]