长效抗菌材料预防急性尿潴留患者留置导尿管相关尿路感染的成本-效果分析  

Cost-effectiveness Analysis of Long-acting Antimicrobial Materials in Preventing Urinary Tract Infections Associated with Indwelling Catheters in Patients with Acute Urinary Retention

作　　者：陈群飞[1] 王东敏 马佩芬[1] 李理然 王志平[1] CHEN Qun-Fei;WANG Dong-Min;MA Pei-Fen;LI Li-Ran;WANG Zhi-Ping(Second Hospital of Lanzhou University,Lanzhou 730010,China;Medical College of Northwest Minzu University,Lanzhou 730010,China;School of Health and Related Research,The University of Sheffield,Sheffield S102TN,Britain)

机构地区：[1]兰州大学第二医院,兰州730010 [2]西北民族大学医学院,兰州730010 [3]谢菲尔德大学健康与相关问题研究学院,谢菲尔德S102TN

出　　处：《中国药物经济学》2019年第10期5-7,11,共4页China Journal of Pharmaceutical Economics

基　　金：甘肃省青年科技基金计划(1606RJYA230和17JR5RA280);甘肃省科技厅技术研究与开发专项(1305TCYA015);白银市科技计划项目(2018-2-42Y)

摘　　要：目的分析长效抗菌材料(JUC)预防急性尿潴留患者导尿管相关尿路感染(CAUTI)的成本-效果。方法以急性尿潴留患者233例为研究对象,并随机分为JUC组(116例)和安慰剂组(117例),实施多中心随机对照试验并收集成本数据,并进行成本-效果分析。结果 JUC组治疗7 d CAUTI发生率为12.82%,明显低于安慰剂组41.38%,差异有统计学意义(P<0.05)。增量成本-效果比(ICER)结果显示每多预防1%的7 d CAUTI发生率,JUC组与安慰剂组比较少花费187.28元。结论 JUC能有效预防急性尿潴留患者发生CAUTI,且更具成本-效果优势。Objective To analyze the cost-effectiveness of nanotechnology antibacterial spray(JUC) in preventing catheter-related urinary tract infection(CAUTI) in patients with acute urinary retention. Methods A total of 233 patients with acute urinary retention were randomly divided into the JUC group(116 patients) and the placebo group(117 patients). A multicenter randomized controlled trial was conducted and cost data was collected and cost-effectiveness analysis was performed. Results The incidence of 7-day CAUTI in the JUC group was 12.82%, which was significantly lower than that in the placebo group(41.38%)(P<0.05). The incremental cost-effectiveness ratio(ICER) results showed a 1% 7-day CAUTI incidence per prevention resulted in 187.28 less for the JUC group, compared with the placebo group. Conclusion JUC can effectively prevent CAUTI in patients with acute urinary retention and has a cost-effective advantage.

关 键 词：长效抗菌材料 急性尿潴留 导尿管相关尿路感染 成本-效果分析 

分 类 号：R691.3[医药卫生—泌尿科学] R956[医药卫生—外科学]