抑郁症患者服药依从性及其相关影响因素的研究  

Factors associated with medication adherence among with depressive disorder

作　　者：符晓艳[1] 王华[1] 马瑞雪[1] 江礼[1] 陈月[1] 雷利 Fu Xiaoyan;Wang Hua;Ma Ruixue;Jiang Li;Chen Yue;Lei Li(Department of Neurology,Field Surgery Research Institute,Daping Hospital of Army Medical University,Chongqing,400042,China)

机构地区：[1]陆军军医大学大坪医院野战外科研究所神经内科

出　　处：《中国医师杂志》2019年第11期1663-1666,共4页Journal of Chinese Physician

摘　　要：目的探讨抑郁症患者服药依从性及其相关影响因素。方法选取2015年1月至2017年12月就诊于本院的抑郁症患者406例为研究对象。就诊时收集患者一般资料,随访6个月时采用服药依从问卷量表进行评分。根据评分结果将406例患者分为高依从组、中依从组和低依从组,比较分析抑郁症患者服药依从性与人文因素、合并慢性病、病程等影响因素的相关性。结果中、高依从组年龄≥60岁、受教育时间≤6年、无配偶、农民、月收入<3000元、自费医疗、失眠史、独居、负性生活事件的比例明显低于低依从组,中、高依从组干部比例、中依从组工人比例明显高于低依从组,差异有统计学意义(P<0.05)。中、高依从组患者病程明显短于低依从组,差异有统计学意义(P<0.01)。Logistic回归分析显示,受教育≤6年、无配偶、农民、低收入、自费医疗、独居、负性生活事件、病程>6年与抑郁症患者服药依从性低独立相关(P<0.05或P<0.01)。结论抑郁症患者服药依从性低,应开展有针对性的健康宣教。特别是病程长的患者,要做好延续护理及长期随访。调动家庭支持系统,关心与尊重患者,减少负性生活事件的发生,提高抑郁症患者的服药依从性,促进患者早日康复。Objective To explore the status of medication adherence among patients with depressive disorder and analyze its potential influencing factors. Methods A total of 406 patients with depression who visited our hospital from January 2015 to December 2017 were selected as subjects of study. General data of patients were collected at the time of consultation,and drug adherence questionnaire was used to score the patients at 6 months of follow-up. According to the score,406 patients were divided into high adherence group,middle adherence group and low adherence group,the correlation between medication adherence and humanistic factors,chronic diseases and course of disease was analyzed. Results Compared with the low adherence group,the proportion of age( > 60 years old),education( < 6 years),no spouse,peasant,monthly income( <3 000 yuan),self-funded medical treatment,insomnia history,solitude and negative life events decreased significantly in the middle and high adherence groups. Cadre ratio and the proportion of workers in the middle adherence group increased significantly( P < 0. 05). Compared with the low adherence group,the course of disease in the middle and high adherence group was significantly shorter( P < 0. 01). Logistic regression analysis showed that education < 6 years,no spouse,farmers,low income,self-paid medical treatment,solitude,negative life events,course of disease were independently correlated with low adherence of depression patients( P < 0. 05 or P < 0. 01). Conclusions Depression patients have low adherence with medication,so targeted health education should be carried out. Especially for patients with a long course of illness,continuous nursing and long-term follow-up should be done well. Mobilizing family support system,caring for and respecting patients can effectively reduce the occurrence of negative life events. It can improve the medication adherence of depressive patients and promote their early recovery.

关 键 词：抑郁症 服药依从性 因素分析 统计学 

分 类 号：R47[医药卫生—护理学]