中药雾化治疗鼻咽癌患者放射性口腔黏膜炎临床研究  

Clinical Study on Aerosol Inhalation of Chinese Medicine in Treatment of Radiation-induced Oral Mucositis in Patients with Nasopharyngeal Carcinoma

作　　者：何小红 马柳 李园 黄晶晶 杜程 曾春玲 李美愉 高志娟 HE Xiaohong;MA Liu;LI Yuan;HUANG Jingjing;DU Cheng;ZENG Chunling;LI Meiyu;GAO Zhijuan(The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二附属医院

出　　处：《山东中医杂志》2019年第11期1046-1050,共5页Shandong Journal of Traditional Chinese Medicine

摘　　要：目的:探讨中药雾化治疗鼻咽癌患者放射性口腔黏膜炎的临床疗效。方法:108例放射治疗致放射性口腔黏膜炎的鼻咽癌患者按随机数字表法分为对照组和治疗组各54例,对照组给予常规口腔治疗(药液含漱),治疗组在对照组的基础上加用中药雾化吸入。比较两组临床疗效及治疗前后卡氏量表(KPS)评分、疼痛数字量表(NRS)评分、口腔黏膜损伤程度及唾液中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平。结果:治疗组总有效率90.74%,对照组79.63%,两组疗效比较,差异有统计学意义(P<0.05)。两组治疗后NRS评分、KPS评分较治疗前均改善,且治疗组改善程度较对照组更明显,差异有统计学意义(P<0.05)。治疗后,两组口腔黏膜损伤程度较治疗前均改善,且治疗组改善程度较对照组更明显,差异有统计学意义(P<0.05)。两组唾液TNF-α、IL-6、CRP水平治疗后均降低,且治疗组降低更明显(P<0.05)。结论:中药雾化吸入可以提高鼻咽癌患者放射性口腔黏膜炎的疗效,预防口腔感染,改善症状,抑制炎症反应。Objective:To observe the clinical efficacy of aerosol inhalation of Chinese medicine on radiation-induced oral mucositis in patients with nasopharyngeal carcinoma. Methods:A total of 108 patients with radiation-induced oral mucositis caused by radiotherapy for nasopharyngeal carcinoma were divided into control group and treatment group by the random number table,with 54 cases in each group. Patients in the control group were given conventional medical treatment(gargle) and those in the treatment group were treated with aerosol inhalation of Chinese medicine in addtion to the conventional medical treatment. The clinical curative efficacy,Karnofsky performance status scale(KPS) score,numerical rating scale(NRS) score,degree of oral mucosal injury and levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP) in salivary of the two groups were compared before and after treatment. Results:The total effective rate was 90.74% in the treatment group and 79.63% in the control group. The difference of clinical efficacy between the two groups were statistically significant(P<0.05). After treatment,the NRS scores and KPS scores of the two groups were improved and the improvement of the treatment group was more obvious than that of the control group. The differences of the scores between the two groups were statistically significant(P<0.05). After treatment,the degree of oral mucosal injury in both groups was improved and the improvement of the treatment group was more obvious than that of the control group. The difference was statistically significant(P<0.05). After treatment,the levels of TNF-α,IL-6 and CRP in salivary of the two groups were decreased and the decrease of the treatment group was more obviously than that of the control group(P<0.05). Conclusion:Aerosol inhalation of Chinese medicine can improve the curative efficacy,prevent oral infection,improve symptoms and inhibit inflammation in the treatment of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma.

关 键 词：中药雾化 鼻咽癌 放射性口腔黏膜炎 卡氏量表评分 数字量表评分 口腔黏膜损伤 

分 类 号：R273[医药卫生—中西医结合]