基于文献研究的中西医结合治疗幽门螺杆菌相关性胃病中中药用药规律分析  

Medication regularity of combination of traditional Chinese medicine and Western medicine in treating Helicobacter pylori-related gastropathy based on literatures

作　　者：张彧[1] 吴东升[1] 徐寅[2] 喻斌[2] ZHANG Yu;WU Dong-sheng;XU Yin;YU Bin(Hunan University of Chinese Medicine,Changsha 410208,China;First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中国中药杂志》2019年第22期4985-4991,共7页China Journal of Chinese Materia Medica

基　　金：湖南省教育厅科研计划项目(2016C1237);湖南省中医药科研计划重点项目(201512);湖南中医药大学中医学国内一流建设学科(2018—2010年)

摘　　要：整理分析中西医结合治疗幽门螺杆菌(Hp)相关性胃病中的中药用药规律,为临床治疗Hp相关性胃病提供参考。检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wan Fang)、维普网(VIP)、中国生物医学文献数据库(CBM)中中西医结合治疗Hp相关性胃病的文献为数据源,筛选并用Excel软件和中医传承辅助平台建立方剂数据库进行统计分析及挖掘用药规律。共纳入合格文献178篇,其中77篇明确中医证型,脾胃湿热证出现频次最高;共使用方剂207次,其中经典方剂使用100次,半夏泻心汤使用频次最多;共使用中药3027次,包括不同中药207味,使用频次前三的单味中药分别是甘草、黄连、半夏。中药四气以寒温并见,五味以苦辛居多,多归属于脾经、胃经和肝经;运用数据挖掘技术挖掘核心药物组合21个,得到新方12首。运用数据挖掘技术可以发现治疗Hp相关性胃病主要从“驱邪”及“补虚”两方面进行,同时注重调畅气机,用药具有寒温并用、辛开苦降的配伍特点。这对于优化临床处方、提高疗效及新药研发有一定参考作用。The medication rules of combination of traditional Chinese medicine( TCM) and Western medicine in treating Helicobacter pylori-related gastropathy are analyzed to provide reference for clinical Helicobacter pylori-related gastropathy. Relevant literatures on integrated traditional Chinese and Western medicine in the treatment of Helicobacter pylori-related gastropathy were collected in CNKI,Wan Fang,VIP and CBM. Excel software and traditional Chinese medicine inheritance support system were used to establish a prescription database for data mining and analysis of the medication rules. A total of 178 literatures were selected,77 of them indicated TCM syndromes,and the syndrome of dampness-heat in the spleen and stomach had the highest frequency. A total of 207 prescriptions were used,including 100 classic prescriptions,and Banxia Xiexin Decoction had the highest frequency. Traditional Chinese medicine materials were used for 3 027 times,involving 207 herbs,and the top three mostly frequently used herbs were Glycyrrhiza uralensis,Coptis chinensis,and Pinellia ternata. The herbs mostly featured cold and warm properties in four natures,and bitterness and pungent in five flavors,and enter spleen,stomach and liver meridians. Totally 21 core drug combinations and 12 new prescriptions were obtained. According to data mining,the treatment of Helicobacter pylori-related gastropathy gives priority to " dispelling evil" " tonifying deficiency" and regulating Qi. The medication rules were the combination of cold and warm herbs and the compatibility of acrid opening and bitter down-bearing herbs. This provides a certain reference for optimizing clinical prescriptions,improving efficacy,and developing new drugs.

关 键 词：Hp相关性胃病 中药 用药规律 数据挖掘 中医传承辅助平台 

分 类 号：R28[医药卫生—中药学]