青蒿素类药物对T细胞免疫调节作用研究进展  

Research progress of effect of artemisinin family drugs on T lymphocytes immunomodulation

作　　者：闫思超 李玉洁[1,2] 王娅杰[2] 蔡维艳[2] 翁小刚[2] 李琦[2] 陈颖[2] 杨庆[2] 朱晓新[1,2] YAN Si-chao;LI Yu-jie;WANG Ya-jie;CAI Wei-yan;WENG Xiao-gang;LI Qi;CHEN Ying;YANG Qing;ZHU Xiao-xin(Research Center of Artemisinin.,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院青蒿素研究中心,北京100700 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2019年第22期4992-4999,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金应急管理项目(81641002);国家“重大新药创制”科技重大专项(2017ZX09101002,2017ZX09101002-001-001-3,2017ZX09101002-002-008);中央级公益性科研院所基本科研业务费专项(ZXKT7043,2017ZZ10-024)

摘　　要：青蒿素是从中国传统中药黄花蒿中提取得到的有效抗疟成分,以其独有的倍半萜和双氧桥为基础化学结构,科学家们又进一步提取合成得到以双氢青蒿素、青蒿琥酯、蒿甲醚、蒿乙醚等为代表的多种具有不同作用特点的衍生物,在不同类型疾病中表现出潜在药效作用,引起广泛关注。其中青蒿素类药物被发现在不同类型疾病中参与对T细胞免疫的调节过程,能够影响T细胞激活、增殖、分化、凋亡以及亚群功能等诸多关键环节。T细胞免疫在多种疾病病理过程中发挥重要作用,影响发病过程、治疗效果及疾病预后,以此为靶点的药物研发也在近年来成为研究热点。T细胞免疫功能呈网络调控,机制复杂,青蒿素类药物对T细胞免疫调节的研究尚在起步阶段,且涉及多种不同类型疾病,对已有研究成果进行总结有利于展开对其作用特点及机制的系统阐释和深入挖掘。该文就青蒿素类药物对T细胞免疫的调节作用,从疟疾、自身免疫病、超敏反应、肿瘤、血吸虫病及艾滋病几个方面总结研究进展,为相关研究提供基础。Artemisinin was isolated from traditional Chinese herb Artemisia annua for treating malaria.A series of derivatives,like dihydroartemisinin,artesunate,artemether,artether,had the same core chemical structure,and sesquiterpene lactone containing peroxide bridge constitute the basic chemical structure.Besides anti-malaria,artemisinin family drugs were found to ameliorate many different diseases,which have attracted wide attention in recent years.Among different diseases,artemisinin family drugs were found to have T lymphocytes immunomodulation effects,including activation,proliferation,differentiation,apoptosis and subsets function.Because T cell immunologic response is the key point of many diseases,and impact the pathogenic process,therapeutic effect and prognosis,the drug studies with it as the target have become hotspots in recent years.Studies of artemisinin family drug on T cell immunomodulation were still at the initial stage and involved in different disease;furthermore,T cell immune process involves complicated molecu?lar mechanism,it is imperative to summarize the advance of current studies for further systematic explanation and exploration of their characteristics and mechanisms.This article will summarize the research progress of artemisinin family drugs for malaria,autoimmune disease,hypersensitivity reaction,tumor,schistosomiasis and AIDS relating to T cell immune modulation,so as to provide basic and professional reference for related research and application.

关 键 词：青蒿素 T细胞 免疫调节 适应性免疫 免疫抑制 

分 类 号：R28[医药卫生—中药学]