双联抗血小板凝聚对轻型卒中患者血清hs-CRP、Hcy的影响  

Effect of Double Antiplatelet Aggregation on Serum hs-CRP and Hcy in Patients with Mild Cerebral Apoplexy

作　　者：李鹏董[1] 苏梅云 马梅花[1] 陈东明[1] 陈振杰[1] 林进[1] LI Pengdong;SU Meiyun;MA Meihua;CHEN Dongming;CHEN Zhenjie;LIN Jin(Anxi County Hospital,Anxi 362400,China)

机构地区：[1]安溪县医院

出　　处：《中外医学研究》2019年第31期18-19,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：泉州市卫生计生科研资助项目(项目编号：泉卫计函[2015]248号)

摘　　要：目的:分析双联抗血小板凝聚对缺血性轻型卒中患者血清hs-CRP、Hcy的影响。方法:选取2015年11月-2018年6月笔者所在医院轻型卒中患者119例,根据随机计算机表法分为两组,其中观察组74例,给予阿司匹林、氯吡格雷联合治疗;对照组45例,给予阿司匹林治疗。比较两组治疗前后血清hs-CRP、Hcy水平,观察两组进展性脑梗死的发生率及6个内不良反应发生情况。结果:两组治疗后Hcy、hs-CRP水平均明显下降,且治疗后观察组Hcy、hs-CRP水平低于对照组,差异均有统计学意义(P<0.05);观察组治疗后进展性梗死及6个月内复发率低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双联抗血小板凝聚能明显降低轻型卒中Hcy、hs-CRP水平,减缓病情进展,降低复发率。Objective: To analyze the effects of double antiplatelet on serum hs-CRP and Hcy in patients with mild cerebral apoplexy. Method: A total of 119 patients with mild cerebral apoplexy in our hospital from November 2015 to June 2018 were selected and divided into two groups according to random computer table. Seventy-four patients in the observation group, who were given Aspirin and Clopidogrel. Forty-five patients in the control group were treated with Aspirin. Serum levels of hs-CRP and Hcy were compared before and after treatment. The incidence of progressive cerebral infarction and 6 adverse reactions were observed. Result: After treatment, the levels of Hcy and hs-CRP decreased in both groups, and the levels of Hcy and hs-CRP in the observation group were lower than those in the control group, the differences were statistically significant(P<0.05). And the rates of progressive infarction and recurrence within 6 months in the observation group were lower than those in the control group, the differences were statistically significant(P<0.05). The adverse reactions rate between the two groups was compared, and the difference was not statistically significant(P>0.05). Conclusion: Double antiplatelet aggregation can significantly reduce the levels of Hcy and hs-CRP in mild cerebral apoplexy, and reduce the progression and recurrence rate.

关 键 词：轻型卒中 阿司匹林 氯吡格雷 同型半胱氨酸 高敏C反应蛋白 

分 类 号：R54[医药卫生—心血管疾病]