激素治疗特发性肺含铁血黄素沉着症37例效果观察  

Effects of corticosteroids on 37 cases of idiopathic pulmonary hemosiderosis

作　　者：赵雪莲[1] 王西阁[1] 宋丽丽[1] 梁宇[1] 李四保[1] 臧文涛 Zhao Xuelian;Wang Xige;Song Lili;Liang Yu;Li Sibao;Zang Wentao(Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院儿内科,450052

出　　处：《中国实用医刊》2019年第20期49-51,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨激素治疗特发性肺含铁血黄素沉着症(IPH)的效果.方法回顾性分析2013年1月至2019年1月郑州大学第三附属医院收治的37例IPH患儿的临床资料,所有患儿均采用糖皮质激素进行治疗.分析患儿一般资料、治疗效果及治疗前后肺功能的变化.结果37例患儿中有肺出血影像表现25例,肺出血吸收期影像表现9例,肺野透亮度明显减低影3例.治疗后12个月,总有效率为86.48%(32/37),37例患儿用力肺活量、第1秒用力呼气容积、最大肺活量及用力呼出50%、75%肺活量时的瞬间流速(FEF50、FEF75)较治疗前升高(P<0.05).结论激素治疗IPH可有效改善患儿肺部影像学表现及临床症状,改善患儿肺功能,有助于临床控制病情.Objective To investigate the effects of corticosteroids on idiopathic pulmonary hemosiderosis(IPH).Methods The clinical data of 37 children with IPH admitted to the Third Affiliated Hospital of Zhengzhou University from January 2013 to January 2019 were retrospectively analyzed.All patients were treated with glucocorticoids.The general data,treatment effects and changes in lung function before and after treatment were analyzed.Results Among the 37 patients,there were 25 cases of pulmonary hemorrhage,9 cases of pulmonary hemorrhage absorption,and 3 cases of lung field transparency according to imaging study.After 12 months of treatment,the total effective rate was 86.48%(32/37),and forced vital capacity,forced expiratory volume in 1 second,maximum vital capacity,forced exhalation of 50%,and 75%of vital capacity in 37 children were higher than those before treatment(P<0.05).Conclusions Glucocorticoids in the treatment of IPH can effectively improve the pulmonary imaging,hemogram and the pulmonary function of children,which is helpful to control the condition in clinical.

关 键 词：肺含铁血黄素沉着症 特发性 糖皮质激素 肺功能 

分 类 号：R72[医药卫生—儿科]