孟鲁司特钠溶液光降解动力学研究  

Study on photodegradation kinetics of montelukast sodium solution

作　　者：何朝星[1] 王丽婧 何函星 王晓晖[1] 杜青[1] HE Chao-xing;WANG Li-jing;HE Han-xing;WANG Xiao-hui;DU Qing(Hebei Medical University,Shijiazhuang 050017,China;Yiling Pharmaceutical Corporation,Shijiazhuang 050000,China;The First Hospital of Shijiahuang City,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学,石家庄050017 [2]石家庄以岭药业股份有限公司,石家庄050000 [3]石家庄市第一医院,石家庄050011

出　　处：《药物分析杂志》2019年第11期2070-2075,共6页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:考察孟鲁司特钠溶液光降解反应的动力学特征及影响因素。方法:对不同浓度的孟鲁司特钠55%甲醇溶液进行光照试验,采用HPLC法测定不同时间孟鲁司特钠及光解产物的浓度,拟合动力学方程并计算动力学参数。结果:孟鲁司特钠的降解速度和光解产物的生成速度随孟鲁司特钠初浓度的增加而减小,在一定范围内,孟鲁司特钠的降解反应为一级反应,光解产物的生成反应为零级反应。结论:孟鲁司特钠溶液对光不稳定,其降解速度受浓度影响显著。Objective:To inverstigate the photodegradation kinetic characteristics and influence factors of montelukast sodium solution.Methods:The illumination tests were carried out for 55% methanol solution of montelukast sodium with different concentrations.HPLC method was used to determine the concentrations of montelukast sodium and its photolysis product at different time.The kinetic equations were fitted and the kinetic parameters were calculated.Results:Both the degradation rate of montelukast sodium and the formation rate of photolysis product were decreased with the increase of initial concentration of montelukast sodium.Within a certain range,the degradation reaction of montelukast sodium uas a first-order reaction,and the photolysis product formation reaction uas a zero-order reaction.Conclusion:The montelukast sodium solution is unstable to light,and its degradation rate is significantly affected by the concentration.

关 键 词：孟鲁司特钠 光降解反应 动力学方程 化学稳定性 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]