芪白平肺胶囊对慢性阻塞性肺疾病气道黏液高分泌大鼠的保护作用研究  

Protective effect of Qibai Pingfei Capsules on COPD airway mucus hypersecretion model rats

作　　者：王传博[1,2] 李泽庚 方莉 童佳兵 杨程[2,3] 朱洁 张星星[2,3] WANG Chuan-bo;LI Ze-geng;FANG Li;TONG Jia-bing;YANG Cheng;ZHU Jie;ZHANG Xing-xing(Department of Traditional Chinese Medicine,The Second Hospital of Anhui Medical University,Hefei 230601,China;Institute of Medicine for Respiratory Disease,Anhui Academy of Chinese Medicine,Hefei 230038,China;Respiratory Department,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽医科大学第二附属医院中医科,合肥230601 [2]安徽省中医药科学院呼吸病防治研究所,合肥230038 [3]安徽中医药大学第一附属医院呼吸科,合肥230031

出　　处：《中华中医药杂志》2019年第11期5407-5410,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81202808)~~

摘　　要：目的:探讨芪白平肺胶囊对慢性阻塞性肺疾病(COPD)气道黏液高分泌大鼠的保护作用。方法:通过复制COPD气道黏液高分泌大鼠模型,给予芪白平肺胶囊、氨溴索、泼尼松干预,ELISA检测肺泡灌洗液(BALF)及血清中IL-6、血小板源生长因子A(PDGF-A)、单核细胞趋化蛋白-1(MCP-1)、高迁移率族蛋白B1(HMGB1)。Western Blot检测肺组织HMGB1的表达。结果:芪白平肺组较模型组及氨溴索组BALF及血清中IL-6、PDGF-A、MCP-1、HMGB1均明显减少(P<0.01)。芪白平肺组较模型组肺组织HMGB1表达显著减少(P<0.01)。结论:研究表明芪白平肺胶囊可以减少COPD模型大鼠炎症细胞的浸润,对COPD气道黏液高分泌模型大鼠有保护作用。Objective: To investigate the protective effect of Qibai Pingfei Capsules on chronic obstructive pulmonary disease(COPD) airway mucus hypersecretion model rats. Methods: The COPD airway mucus hypersecretion rat model was duplicated, and Qibai Pingfei Capsules, Ambroxol and Prednisone were given to intervene, and the related indicators such as BALF、IL-6、PDGF-A、MCP-1、HMGB1 were detected by ELISA. The expression of HMGB1 in lung was detected by Western Blot. Results: The levels of IL-6, PDGF-A, MCP-1 and HMGB1 in Qibaiping lung group were significantly lower than those in model group(P<0.01). Western Blot test showed that the expression of HMGB1 in lung tissue of Qibaiping lung group was significantly lower than that of model group(P<0.01). Conclusion: Qibai Pingfei Capsules can reduce the infiltration of inflammatory cells in COPD model rats and has protective effect on COPD airway mucus hypersecretion model rats.

关 键 词：慢性阻塞性肺疾病 炎症细胞因子 芪白平肺胶囊 气道黏液高分泌 

分 类 号：R56[医药卫生—呼吸系统]