CO2点阵激光联合他克莫司软膏治疗白癜风的疗效观察  

Effectiveness and Safety of Fractional CO2 Laser Combined with Tacrolimus Ointment for the Treatment of Vitiligo

作　　者：许教雄[1] 何仁亮 李凤春[1] 黄桃源 吴树毅 XU Jiaoxiong;HE Renliang;LI Fengchun;HUANG Taoyuan;WU Shuyi(Department of Dermatology,Huangpu People's Hospital of Zhongshan City,Zhongshan 528429,China;Dermatology Hospital of Southern Medical University,Guangzhou 510091,China;Guangdong Provincial Dermatology Hospital,Guangzhou 510091,China;Department of Dermatology,Zhongshan Traditional Chinese Medicine Hospital,Zhongshan 528400,China)

机构地区：[1]中山市黄圃人民医院皮肤科,广东中山528429 [2]南方医科大学皮肤病医院,广东广州510091 [3]广东省皮肤病医院,广东广州510091 [4]中山市中医院皮肤科,广东中山528400

出　　处：《中国皮肤性病学杂志》2019年第12期1451-1455,共5页The Chinese Journal of Dermatovenereology

摘　　要：目的观察CO2点阵激光联合他克莫司软膏治疗白癜风的临床疗效。方法73例白癜风患者随机分为两组,治疗组(37例)采用CO2点阵激光治疗,每4周1次,共3次;对照组(36例)采用窄谱中波紫外线治疗,2次/周,两组均外用0.1%他克莫司软膏,2次/d,疗程12周。两组在疗程结束后评价疗效。结果治疗组有效率高于对照组,疗效比较差异具有统计学意义(P<0.05);治疗组面颈部、四肢、手足的疗效及白斑开始复色时间均优于对照组,差异具有统计学意义(P<0.05),两组患者躯干的疗效及白斑开始复色时间差异无统计学意义(P>0.05)。两组患者治疗期间均未出现严重不良反应。结论CO2点阵激光联合他克莫司软膏治疗白癜风疗效优越、不良反应小,可作为治疗白癜风的新方法。Objective To determine the efficacy of fractional CO2 laser therapy combined with tacrolimus ointment in the treatment of vitiligo.Methods Seventy-three patients with vitiligo were randomly divided into the treatment group(37 cases)and the control group(36 cases).The treatment group received fractional CO2 laser treatment,once every four weeks for 3 times in total,the control group received narrow-band ultraviolet B treatment,twice per week.All the patients received 0.1%tacrolimus ointment therapy for 12 weeks.The therapy efficacy was observed after finishing treatment.Results The effective rate in the treatment group was significantly higher than that in the control group(P<0.05).The efficacy and time of repigmentation in some of the anatomic sites(face-neck,limbs and hands-feet)were significantly better in the treatment group than that in the control group(P<0.05).No severe adverse reactions were observed.Conclusion For the treatment of vitiligo,fractional CO2 laser combined with tacrolimus ointment shows remarkable clinical efficacy and less adverse reaction.It is a new method for the treatment of vitiligo.

关 键 词：CO2点阵激光 窄谱中波紫外线 他克莫司 白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]