人体乳腺矿化集合体类型与临床相关性分析  

An analysis of the type of human breast mineralization aggregation and the clinical relevance

作　　者：张岩[1] 李艳[1] 程潇 鲁安怀[1] 王长秋[1] 梅放[2] 柳剑英[2] 王大翠[3] ZHANG Yan;LI Yan;CHENG Xiao;LU An-huai;WANG Chang-qiu;MEI Fang;LIU Jian-ying;WANG Da-cui(Beijing Key Laboratory of Mineral Environmental Function,Peking University,Beijing 100871,China;Pathology Department,School of Basic Medical Science,Health Science Center of Peking University,Beijing 100083,China;Department of Pathology,People’s Hospital of Zhongxiang,Hubei,Zhongxiang 431900,China)

机构地区：[1]矿物环境功能北京市重点实验室,北京大学,北京100871 [2]北京大学医学部基础医学院病理学系,北京100083 [3]钟祥市人民医院病理科,湖北钟祥431900

出　　处：《岩石矿物学杂志》2019年第6期861-870,共10页Acta Petrologica et Mineralogica

基　　金：国家自然科学基金资助项目(41772033,41272048)~~

摘　　要：选取123例乳腺病理性矿化样品,利用光镜、扫描电镜对乳腺矿化进行了微形貌分类研究,并利用统计学方法探讨了乳腺矿化集合体类型与患者年龄、乳腺病变类型和癌变阶段的相关性。研究发现,根据乳腺矿化在光学显微镜下的可分辨形态,将其分为两种类型:粒状集合体与块状集合体;其中粒状集合体为小于200μm的规则粒状钙化,少部分有环带结构,和有机组织结合紧密;而块状集合体则为大于200μm的片状钙化,形状不规则。统计分析数据显示,随年龄增加,块状集合体出现病理比例增加,粒状集合体出现病理比例减少,敏感年龄分区界限为50岁;粒状集合体在50岁以上和50岁以下患者中单独出现的概率分别为24%和53%;块状集合体在乳腺原位癌(71.4%)患者中占主导,粒状集合体在乳腺纤维腺瘤(64.5%)患者中占主导。该研究可为未来乳腺癌的诊断提供基于乳腺矿化精细矿物学特征的辅助新方法。In this study,the authors chose 123 breast pathological mineralization samples and made a micro-morphology classification study using optical microscope as well as scanning electron microscope.Then,the relationships between the type of breast mineralization and the age of the patient as well as the type of breast lesion and the stage of cancer were discussed by using statistical methods.Based on the resolvable morphology under the optical microscope,the authors divided the mammary mineralization into two types:granular aggregates and massive aggregates;granular aggregates are regular granular calcifications less than 200μm,with a few having rings.The band structure is tightly bound to the organic structure;the block aggregate is assembled by flaky calcification with the size more than 200μm,and the aggregates'shape is irregular.Statistical analysis shows that,with the increase of age,the pathological proportion of the aggregates increases,while the pathological proportion of the granular aggregates decreases,and the sensitive age partition is 50 years old;the granular aggregates appear separately in patients over 50 years old and under 50 years old.The probabilities are 24%and 53%,respectively;the mass aggregates are predominant in patients with breast carcinoma in situ(71.4%),and the granulating aggregates are predominant in patients with breast fibroadenomas(64.5%).This study can provide a new auxiliary method for the diagnosis of breast cancer based on the refined mineralogical feature of breast mineralization.

关 键 词：乳腺病变 矿化集合体 影像学 癌变 

分 类 号：P579[天文地球—矿物学]