CLOVES综合征临床实践指南  

Clinical practice guidelines for CLOVES syndrome(translation version)

作　　者：张凌[1] 陈正岗(编译)[2] 郑家伟(审校)[1] ZHANG Ling;CHEN Zheng-gang;ZHENG Jia-wei(Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine/National Clinical Research Center for Oral Disease/Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology.Shanghai 200011;Department of Oral and Maxillofacial Surgery,Qingdao Municipal Hospital Group.Qingdao 266011,Shandong Province,China)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011 [2]青岛市市立医院口腔颌面外科,山东青岛266011

出　　处：《中国口腔颌面外科杂志》2019年第6期554-559,共6页China Journal of Oral and Maxillofacial Surgery

摘　　要：CLOVES综合征(congenital lipomatous overgrowth,vascular malformations,epidermal nevi,scoliosis/skeletal/spional anomalies,CLOVES)是一种罕见的遗传性血管性疾病,临床特征包括先天性脂肪瘤过度生长、脉管畸形、皮肤痣、脊柱侧凸、骨骼或脊柱异常等。该病的病因及发病机制目前尚不明确,患者的症状和严重程度存在明显的个体差异。其治疗目的在于缓解症状以及降低发生并发症的风险。本文对CLOVES的临床表现及诊断方面的研究进行回顾,并为患者的管理提供指导。CLOVES syndrome is a rare congenital vascular disorder with the following clinical features:congenital lipomatous overgrowth,vascular malformations,epidermal nevi,scoliosis/skeletal/spional anomalie.The etiology and pathogenesis remain unknown.Symptoms and severity of CLOVES vary greatly among each individual.The goals of treatment are to alleviate symptoms and minimize the risk of complications.This article reviewed the clinical presentation and diagnostic studies,and provided management guidelines to help care for patients with this syndrome.

关 键 词：CLOVES综合征 先天性脂肪瘤过度生长 脉管畸形 表皮痣 脊柱侧凸 骨骼、脊柱异常 临床实践指南 

分 类 号：R543[医药卫生—心血管疾病]