自拟益气活血汤辅助治疗急性心肌梗死后心力衰竭的临床研究  

Clinical research of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction

作　　者：徐慕娟[1] 王玲[1] 韩钺[1] XU Mujuan;WANG Ling;HAN Yue(Department of Critical Care Medicine,Shenzhen Traditional Chinese Medicine Hospital,Guangdong Province,Shenzhen518033,China)

机构地区：[1]深圳市中医院重症医学科

出　　处：《中国医药导报》2019年第33期129-132,共4页China Medical Herald

基　　金：广东省医学科研基金立项项目(A2016231)

摘　　要：目的探讨自拟益气活血汤辅助治疗急性心肌梗死(AMI)后心力衰竭的临床效果。方法选取深圳市中医院2015年6月~2019年2月收治的AMI后心力衰竭患者80例,按随机数字表法分为对照组(40例)和研究组(40例)。对照组患者采用常规治疗,研究组在对照组基础上加用自拟益气活血汤治疗,两组患者连续治疗2周。检测并比较两组治疗前后左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、中心静脉压(CVP)、心率(HR)及血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)、内皮素(ET)、一氧化氮(NO)水平。观察两组治疗期间的不良反应发生情况。结果两组治疗后LVEF高于治疗前,LVEDD、CVP低于治疗前,HR慢于治疗前,且研究组治疗后LVEF、LVEDD、CVP及HR均较对照组改善明显,差异有高度统计学意义(P<0.01)。两组治疗后血清hs-CRP、TNF-α水平均低于治疗前,IL-10水平高于治疗前,且研究组治疗后血清hs-CRP、TNF-α及IL-10水平均较对照组改善明显,差异有高度统计学意义(P<0.01)。两组治疗后血清ET水平低于治疗前,NO水平高于治疗前,且研究组治疗后血清ET、NO水平均较对照组改善明显,差异有高度统计学意义(P<0.01)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论自拟益气活血汤辅助治疗AMI后心力衰竭的临床效果显著,能明显改善心功能、机体炎性反应,调节血管内皮功能,且安全性较好。Objective To investigate clinical efficacy of self-made Yiqi Huoxue Decection adjuvant therapy in the treatment of heart failure after acute myocardial infarction(AMI).Methods Eighty patients with heart failure after AMI admitted to Shenzhen Traditional Chinese Medicine Hospital from June 2015 to February 2019 were divided into control group(40 cases)and study group(40 cases)according to random number table method.The patients in control group were treated with conventional treatment.The patients in study group were treated with self-made Yiqi Huoxue Decoction on the basis of control group.The patients in two groups were treated for 2 weeks continuously.The left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),central venous pressure(CVP),heart rate(HR),serum levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),endothelin(ET),nitric oxide(NO)were measured and compared between two groups before and after treatment.The adverse reactions of two groups during the treatment were observed.Results After treatment,LVEF was higher than that before treatment,LVEDD was less than that before treatment,CVP was lower than that before treatment,HR was slower than that before treatment in two groups;after treatment,LVEF,LVEDD,CVP and HR in study group were significantly improved compared with those in control group,the differences were highly statistically significant(P<0.01).After treatment,the levels of serum hs-CRP and TNF-αwere lower than those before treatment,the level of IL-10 was higher than that before treatment in two groups;after treatment,the levels of serum hs-CRP,TNF-αand IL-10 in study group were significantly improved compared with those in control group,the differences were highly statistically significant(P<0.01).After treatment,the level of serum ET was lower than that before treatment,the level of serum NO was higher than that before treatment in two groups;after treatment, the levels of ET and NO in study group were s

关 键 词：急性心肌梗死 心力衰竭 自拟益气活血汤 临床效果 

分 类 号：R542.22[医药卫生—心血管疾病]